Selective androgen receptor modulators: current knowledge and clinical applications

ZJ Solomon, JR Mirabal, DJ Mazur… - Sexual medicine …, 2019 - academic.oup.com
Introduction Selective androgen receptor modulators (SARMs) differentially bind to
androgen receptors depending on each SARM's chemical structure. As a result, SARMs …

[HTML][HTML] Selective androgen receptor modulators: the future of androgen therapy?

AR Christiansen, LI Lipshultz, JM Hotaling… - Translational …, 2020 - ncbi.nlm.nih.gov
Selective androgen receptor modulators (SARMs) are small molecule drugs that function as
either androgen receptor (AR) agonists or antagonists. Variability in AR regulatory proteins …

Development of selective androgen receptor modulators (SARMs)

R Narayanan, CC Coss, JT Dalton - Molecular and cellular endocrinology, 2018 - Elsevier
Abstract The Androgen Receptor (AR), a member of the steroid hormone receptor family,
plays important roles in the physiology and pathology of diverse tissues. AR ligands, which …

Selective androgen receptor modulators as function promoting therapies

S Bhasin, R Jasuja - Current Opinion in Clinical Nutrition & …, 2009 - journals.lww.com
Selective androgen receptor modulators as function promoting... : Current Opinion in Clinical
Nutrition & Metabolic Care Selective androgen receptor modulators as function promoting …

Selective androgen receptor modulators (SARMs): a novel approach to androgen therapy for the new millennium

A Negro-Vilar - The Journal of Clinical Endocrinology & …, 1999 - academic.oup.com
Androgen therapy, using injectable, oral and more recently, transdermal preparations, has
been available to physicians for many years to treat a variety of male disorders; to a lesser …

Recent developments in antiandrogens and selective androgen receptor modulators

B Haendler, A Cleve - Molecular and cellular endocrinology, 2012 - Elsevier
The androgens testosterone and dihydrotestosterone play an essential role in the
development and maintenance of primary and secondary male characteristics. Androgens …

Deciphering the selective androgen receptor modulators paradigm

X Zhang, Z Sui - Expert opinion on drug discovery, 2013 - Taylor & Francis
Introduction: The development and potential clinical use of tissue-selective androgen
receptor modulators (SARMs) have advanced tremendously over the past few years. A key …

[HTML][HTML] Discovery and therapeutic promise of selective androgen receptor modulators

J Chen, J Kim, JT Dalton - Molecular interventions, 2005 - ncbi.nlm.nih.gov
Androgens are essential for male development and the maintenance of male secondary
characteristics, such as bone mass, muscle mass, body composition, and spermatogenesis …

Nonsteroidal selective androgen receptor modulators (SARMs): dissociating the anabolic and androgenic activities of the androgen receptor for therapeutic benefit

ML Mohler, CE Bohl, A Jones, CC Coss… - Journal of medicinal …, 2009 - ACS Publications
Interest in the development and therapeutic potential of nonsteroidal tissue-selective
androgen receptor modulators (SARMs) a has increased dramatically within the past …

Pharmacokinetics and pharmacodynamics of nonsteroidal androgen receptor ligands

W Gao, J Kim, JT Dalton - Pharmaceutical research, 2006 - Springer
Testosterone and structurally related anabolic steroids have been used to treat
hypogonadism, muscle wasting, osteoporosis, male contraception, cancer cachexia …