Purpose Augmented renal clearance (ARC) is common in critically ill patients and may lead
to subtherapeutic levels of antibiotics, thus influencing clinical outcomes and emergence of …

Objectives: Augmented renal clearance (ARC) is a state of enhanced renal function
commonly observed in 30%–65% of critically ill patients despite normal serum creatinine …

Background Augmented renal clearance (ARC) is common in critically ill patients and could
result in subtherapeutic antibiotic concentration. However, data in the Asian population are …

Background Traditionally, renal function in critically ill patients has been assessed to identify
renal dysfunction, and dose adjustment is generally accepted in such a context …

Augmented renal clearance (ARC) has been reported in approximately 30–65% of patients
in the intensive care unit (ICU) despite the presence of a normal serum creatinine …

Augmented renal clearance (ARC) refers to the state of heightened renal filtration commonly
observed in the critically ill. Its prevalence in this patient population is a consequence of the …

Highlights•Augmented renal clearance (ARC) is a prevalent condition in the critically
ill.•ARC may result in sub-therapeutic exposure of renally eliminated antibiotics.•Beta …

Objectives: In critically ill patients receiving continuous renal replacement therapy, we aimed
to assess the variability of antibiotic trough concentrations, the influence of effluent flow rates …

Acute kidney injury is very common in critically ill patients requiring renal replacement
therapy. Despite the advancement in medicine, the mortality rate from septic shock can be …

Improved methods to optimize drug dosing in the critically ill are urgently needed. Traditional
prescribing culture involves recognition of factors that mandate dose reduction (such as …