In the last two decades, thanks to the data that have been obtained from the Human
Genome Project and the development of next-generation sequencing (NGS) technologies …

The translation of genomic discoveries to the clinic in pediatric oncology continues to move
forward at a brisk pace. Early adoption of genomics for tumor classification, risk stratification …

The somatic genomic alterations in pediatric cancers to some extent overlap with those seen
in adult cancers, but the exact distribution throughout the genome and the types and …

The sequencing of the human genome had many consequences for the medical field,
perhaps the greatest of which was spurring the development of personalized medicine. A …

With the use of high-throughput molecular profiling technologies, precision medicine trials
are ongoing for adults with cancer. Similarly, there is an interest in how these techniques …

The sequencing of the human genome has raised expectations among the medical and lay
communities that rapid progress will be made in translating this wealth of molecular data into …

The publication of the fourth edition of Principle and Practice of Pediatric Oncology is
occurring at one of the most exciting times in medical history. With the recent completion of …

Background Technological advances including high-throughput sequencing have identified
numerous tumor-specific genetic changes in pediatric and adolescent cancers that can be …

Comprehensive genomic and transcriptomic analysis for guiding therapeutic decisions
provide the basis of precision cancer medicine. In this issue of Cancer Discovery, continued …

Progresses over the past years have extensively improved our capacity to use genome-
scale analyses—including high-density genotyping and exome and genome sequencing …