[HTML][HTML] Activation of endoplasmic reticulum stress in premature aging via the inner nuclear membrane protein SUN2
One of the major cellular mechanisms to ensure cellular protein homeostasis is the
endoplasmic reticulum (ER) stress response. This pathway is triggered by accumulation of …
endoplasmic reticulum (ER) stress response. This pathway is triggered by accumulation of …
Protein sequestration at the nuclear periphery as a potential regulatory mechanism in premature aging
L Serebryannyy, T Misteli - Journal of Cell Biology, 2018 - rupress.org
Despite the extensive description of numerous molecular changes associated with aging,
insights into the driver mechanisms of this fundamental biological process are limited. Based …
insights into the driver mechanisms of this fundamental biological process are limited. Based …
Nuclear softening mediated by Sun2 suppression delays mechanical stress-induced cellular senescence
X Yue, J Cui, Z Sun, L Liu, Y Li, L Shao, Q Feng… - Cell Death …, 2023 - nature.com
Nuclear decoupling and softening are the main cellular mechanisms to resist mechanical
stress-induced nuclear/DNA damage, however, its molecular mechanisms remain much …
stress-induced nuclear/DNA damage, however, its molecular mechanisms remain much …
ESCRT-III controls nuclear envelope deformation induced by progerin
J Arii, F Maeda, Y Maruzuru, N Koyanagi, A Kato… - Scientific Reports, 2020 - nature.com
Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disorder, caused by
mutation in the gene encoding lamin A/C, which produces a truncated protein called …
mutation in the gene encoding lamin A/C, which produces a truncated protein called …
Enhanced nuclear protein export in premature aging and rescue of the progeria phenotype by modulation of CRM1 activity
I García‐Aguirre, A Alamillo‐Iniesta… - Aging …, 2019 - Wiley Online Library
Abstract The study of Hutchinson–Gilford progeria syndrome (HGPS) has provided important
clues to decipher mechanisms underlying aging. Progerin, a mutant lamin A, disrupts …
clues to decipher mechanisms underlying aging. Progerin, a mutant lamin A, disrupts …
Cytoskeleton stiffness regulates cellular senescence and innate immune response in Hutchinson–Gilford Progeria Syndrome
X Mu, C Tseng, WS Hambright, P Matre, CY Lin… - Aging …, 2020 - Wiley Online Library
Hutchinson–Gilford progeria syndrome (HGPS) is caused by the accumulation of mutant
prelamin A (progerin) in the nuclear lamina, resulting in increased nuclear stiffness and …
prelamin A (progerin) in the nuclear lamina, resulting in increased nuclear stiffness and …
The defective nuclear lamina in Hutchinson-gilford progeria syndrome disrupts the nucleocytoplasmic Ran gradient and inhibits nuclear localization of Ubc9
JB Kelley, S Datta, CJ Snow, M Chatterjee… - … and Cellular Biology, 2011 - Am Soc Microbiol
The mutant form of lamin A responsible for the premature aging disease Hutchinson-Gilford
progeria syndrome (termed progerin) acts as a dominant negative protein that changes the …
progeria syndrome (termed progerin) acts as a dominant negative protein that changes the …
A pathway linking oxidative stress and the Ran GTPase system in progeria
S Datta, CJ Snow, BM Paschal - Molecular biology of the cell, 2014 - Am Soc Cell Biol
Maintaining the Ran GTPase at a proper concentration in the nucleus is important for
nucleocytoplasmic transport. Previously we found that nuclear levels of Ran are reduced in …
nucleocytoplasmic transport. Previously we found that nuclear levels of Ran are reduced in …
Imbalanced nucleocytoskeletal connections create common polarity defects in progeria and physiological aging
W Chang, Y Wang, GWG Luxton… - Proceedings of the …, 2019 - National Acad Sciences
Studies of the accelerated aging disorder Hutchinson–Gilford progeria syndrome (HGPS)
can potentially reveal cellular defects associated with physiological aging. HGPS results …
can potentially reveal cellular defects associated with physiological aging. HGPS results …
Nucleolar expansion and elevated protein translation in premature aging
A Buchwalter, MW Hetzer - Nature communications, 2017 - nature.com
Premature aging disorders provide an opportunity to study the mechanisms that drive aging.
In Hutchinson-Gilford progeria syndrome (HGPS), a mutant form of the nuclear scaffold …
In Hutchinson-Gilford progeria syndrome (HGPS), a mutant form of the nuclear scaffold …