One of the major cellular mechanisms to ensure cellular protein homeostasis is the
endoplasmic reticulum (ER) stress response. This pathway is triggered by accumulation of …

Despite the extensive description of numerous molecular changes associated with aging,
insights into the driver mechanisms of this fundamental biological process are limited. Based …

Nuclear decoupling and softening are the main cellular mechanisms to resist mechanical
stress-induced nuclear/DNA damage, however, its molecular mechanisms remain much …

Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disorder, caused by
mutation in the gene encoding lamin A/C, which produces a truncated protein called …

Abstract The study of Hutchinson–Gilford progeria syndrome (HGPS) has provided important
clues to decipher mechanisms underlying aging. Progerin, a mutant lamin A, disrupts …

Hutchinson–Gilford progeria syndrome (HGPS) is caused by the accumulation of mutant
prelamin A (progerin) in the nuclear lamina, resulting in increased nuclear stiffness and …

The mutant form of lamin A responsible for the premature aging disease Hutchinson-Gilford
progeria syndrome (termed progerin) acts as a dominant negative protein that changes the …

Maintaining the Ran GTPase at a proper concentration in the nucleus is important for
nucleocytoplasmic transport. Previously we found that nuclear levels of Ran are reduced in …

Studies of the accelerated aging disorder Hutchinson–Gilford progeria syndrome (HGPS)
can potentially reveal cellular defects associated with physiological aging. HGPS results …

Premature aging disorders provide an opportunity to study the mechanisms that drive aging.
In Hutchinson-Gilford progeria syndrome (HGPS), a mutant form of the nuclear scaffold …