The aim of this study was to prospectively evaluate the frequency, indications, outcomes,
and predictive factors associated with opioid switching, using a protocol that had been …

Goals of work The aims of this study were (1) to prospectively evaluate the clinical benefits of
switching from morphine to an alternative opioid, using oxycodone as first-line alternative …

Opioid switching is the process of changing from one opioid to another to obtain a
satisfactory clinical balance between analgesia and adverse effects. This pharmacological …

Cancer patients with pain may not respond to increasing doses of opioids because they
develop adverse effects before achieving an acceptable analgesia, or the analgesic …

Availability of different WHO-step 3 opioids has encouraged the discussion on their value
and led to the concepts of opioid rotation. Rotation is suggested, when other measures fail to …

In this paper we describe the results of a systematic search of the literature on conversion
ratios during opioid switching. This is part of a project of the European Palliative Care …

According to a Cochrane review on opioid switching, sound evidence on the practice of
substituting one strong opioid with another to improve pain control and reduce adverse …

Opioids, intended to abolish pain, can unexpectedly produce hyperalgesia, particularly
during rapid opioid escalation. Opioid switching could be a therapeutic option in a condition …

Background. The aim of this study was to retrospectively review the chart of cancer patients
switched to methadone for unfavorable response to the previous opioid. Methods …

Background: Opioid therapy is the standard treatment for moderate-to-severe cancer pain
and is becoming a more frequent treatment for moderate-to-severe chronic noncancer pain …