Permeability glycoprotein (P-gp) mediates the export of drugs from cells located in the small
intestine, blood-brain barrier, hepatocytes, and kidney proximal tubule, serving a protective …

The ATP‐binding cassette transporter P‐glycoprotein is now recognized as an important
determinant for disposition of multiple drugs. The use of P‐glycoprotein‐expressing cell …

P‐glycoprotein (P‐gp) is a cell membrane—associated protein that transports a variety of
drug substrates. Although P‐gp has been studied extensively as a mediator of multidrug …

Transport by ATP-dependent efflux pumps such as P-glycoprotein is an increasingly
recognized determinant of drug disposition. P-glycoprotein does not only contribute to …

Permeability-glycoprotein (Pgp) is a drug transporter responsible for the efflux of xenobiotics
out of cells that influence the pharmacokinetics of numerous drugs. However, the role of this …

P-glycoprotein and its role in drug-drug interactions Page 1 137 VOLUME 37 : NUMBER 4 :
AUGUST 2014 ARTICLE Full text free online at www.australianprescriber.com P-glycoprotein …

In humans, there are two P-glycoprotein (P-gp) transporters encoded by MDR1 (PGY1) and
MDR3 (also named MDR2 and PGY3) adjacently located at the chromosomal region 7q21 …

The pharmacological effects of a drug are highly dependent on the absorption, metabolism,
elimination, and distribution of the drug. In the past few years it has become apparent that …

The drug efflux transporter P-glycoprotein (P-gp) is known to confer multidrug resistance in
cancer chemotherapy. The P-gp is highly expressed in many types of tumor cells, as well as …

ABC-type transport proteins, such as P-glycoprotein (P-gp), modify intracellular
concentrations of many substrate compounds. They serve as functional barriers against …