Purpose. In this study, P-glycoprotein (P-gp) mediated efflux of simvastatin (SV), simvastatin
acid (SVA), and atorvastatin (AVA) and inhibition of P-gp by SV, SVA, and AVA were …

Because modulation of P-glycoprotein (Pgp) through inhibition or induction can lead to drug-
drug interactions by altering intestinal, central nervous system, renal, or biliary efflux, it is …

The passage of drugs across cell membranes dictates their absorption, distribution,
metabolism, and excretion. This process is determined by several factors including the …

The mammalian drug-transporting or mdr1-type P-glycoproteins can extrude a range of
structurally diverse, toxic xenobiotic compounds from cells. Our analysis of knockout mice …

P-glycoprotein (P-gp) is crucial in the active transport of various substrates with diverse
structures out of cells, resulting in poor intestinal permeation and limited bioavailability …

Thirty-one structurally diverse marketed central nervous system (CNS)-active drugs, one
active metabolite, and seven non-CNS-active compounds were tested in three P …

Identifying molecules that interact with P-glycoprotein (P-gp) is important for drug discovery
but is also generally reliant on time-consuming in vitro and in vivo studies. As an alternative …

Many orally administered drugs must overcome several barriers before reaching their target
site. The first major obstacle to cross is the intestinal epithelium. Although lipophilic …

Background Numerous knockout mouse studies have revealed that P‐glycoprotein (P‐gp)
significantly limits drug distribution across the mouse blood‐brain barrier (BBB). To …

P-glycoprotein (P-gp) is a polyspecific ATP-dependent transporter linked to multidrug
resistance in cancer; it plays important roles in determining the pharmacokinetics of many …