[HTML][HTML] Activation of serotonin 2C receptors in dopamine neurons inhibits binge-like eating in mice
Background Neural networks that regulate binge eating remain to be identified, and effective
treatments for binge eating are limited. Methods We combined neuroanatomic …
treatments for binge eating are limited. Methods We combined neuroanatomic …
A D2 to D1 shift in dopaminergic inputs to midbrain 5-HT neurons causes anorexia in mice
Midbrain dopamine (DA) and serotonin (5-HT) neurons regulate motivated behaviors,
including feeding, but less is known about how these circuits may interact. In this study, we …
including feeding, but less is known about how these circuits may interact. In this study, we …
[HTML][HTML] 5-HT recruits distinct neurocircuits to inhibit hunger-driven and non-hunger-driven feeding
Obesity is primarily a consequence of consuming calories beyond energetic requirements,
but underpinning drivers have not been fully defined. 5-Hydroxytryptamine (5-HT) neurons …
but underpinning drivers have not been fully defined. 5-Hydroxytryptamine (5-HT) neurons …
Binge‐type eating disrupts dopaminergic and GABAergic signaling in the prefrontal cortex and ventral tegmental area
RLW Corwin, FHE Wojnicki, DJ Zimmer, RK Babbs… - …, 2016 - Wiley Online Library
Objective Binge eating is characterized by repeated intermittent bouts of compulsive
overconsumption of food. Treatment is challenging given limited understanding of the …
overconsumption of food. Treatment is challenging given limited understanding of the …
Delineating a serotonin 1B receptor circuit for appetite suppression in mice
Triptans are a class of commonly prescribed antimigraine drugs. Here, we report a
previously unrecognized role for them to suppress appetite in mice. In particular, frovatriptan …
previously unrecognized role for them to suppress appetite in mice. In particular, frovatriptan …
Anorexia induced by activation of serotonin 5-HT4 receptors is mediated by increases in CART in the nucleus accumbens
A Jean, G Conductier, C Manrique… - Proceedings of the …, 2007 - National Acad Sciences
Anorexia nervosa is a growing concern in mental health, often inducing death. The potential
neuronal deficits that may underlie abnormal inhibitions of food intake, however, remain …
neuronal deficits that may underlie abnormal inhibitions of food intake, however, remain …
[HTML][HTML] Serotonin 1B and 2C receptor interactions in the modulation of feeding behaviour in the mouse
GL Dalton, MD Lee, GA Kennett, CT Dourish… - …, 2006 - Springer
Rationale To examine the functional relationship between 5-HT 1B receptors (5-HT 1B-R)
and 5-HT 2C receptors (5-HT 2C-R) in the control of food intake. Objectives To compare the …
and 5-HT 2C receptors (5-HT 2C-R) in the control of food intake. Objectives To compare the …
[HTML][HTML] Estrogens stimulate serotonin neurons to inhibit binge-like eating in mice
Binge eating afflicts approximately 5% of US adults, though effective treatments are limited.
Here, we showed that estrogen replacement substantially suppresses binge-like eating …
Here, we showed that estrogen replacement substantially suppresses binge-like eating …
A serotonin and melanocortin circuit mediates D-fenfluramine anorexia
Y Xu, JE Jones, DA Lauzon, JG Anderson… - Journal of …, 2010 - Soc Neuroscience
d-Fenfluramine (d-Fen) increases serotonin (5-HT) content in the synaptic cleft and exerts
anorexigenic effects in animals and humans. However, the neural circuits that mediate these …
anorexigenic effects in animals and humans. However, the neural circuits that mediate these …
5‐HT1A receptor binding is increased after recovery from bulimia nervosa compared to control women and is associated with behavioral inhibition in both groups
Objective Because altered serotonin (5‐HT) function appears to persist after recovery from
bulimia nervosa (RBN), we investigated the 5‐HT1A receptor, which could contribute to …
bulimia nervosa (RBN), we investigated the 5‐HT1A receptor, which could contribute to …