The Notch signaling pathway regulates developmental cell-fate decisions and has recently
also been linked to inflammatory diseases. Although therapies targeting Notch signaling in …

Over the past two decades, the Notch signaling pathway has been investigated as a
therapeutic target for the treatment of cancers, and more recently in the context of immune …

The Notch signaling pathway is a fundamental signaling mechanism operating in most, if not
all, multicellular organisms and in most cell types in the body. Like other" ivy league" …

Notch signaling coordinates numerous cellular processes and has been implicated in many
pathological conditions, including rheumatoid arthritis (RA). Although the role of Notch …

The NOTCH gene was identified approximately 110 years ago. Classical studies have
revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors …

The NOTCH (1–4) family of receptors are highly conserved and are critical in regulating
many developmental processes and in the maintenance of tissue homeostasis. Our …

Notch signaling is a well-known key player in the communication between adjacent cells
during organ development, when it controls several processes involved in cell …

Dysregulation of the Notch signaling pathway, which is highly conserved across species,
can drive aberrant epigenetic modification, transcription, and translation. Defective gene …

The Notch signaling pathway regulates important cellular processes involved in stem cell
maintenance, proliferation, development, survival, and inflammation. These responses to …

Canonical Notch signaling is initiated by γ-secretase-mediated cleavage of the Notch
receptor, leading to the release of the active intra-cellular domain of Notch that migrates to …