Statins are a class of low molecular weight drugs that inhibit the rate-limiting enzyme of the
mevalonate pathway 3-hydroxy-3-methylglutaryl-CoA reductase. Statins have been …

Epidemiologic studies of statin use in relation to prostate cancer risk have been
inconclusive. Recent evidence, however, suggests that longer-term use may reduce risk of …

Chemotherapy is the mainstay of treatment for prostate cancer, with paclitaxel being
commonly used for hormone-resistant prostate cancer. However, drug resistance often …

1004 Background: Hydroxymethylglutaryl-CoA reductase inhibitors (statins) are commonly
used to control high cholesterol. These agents that have been shown to induce apoptosis …

In this issue of Cancer Epidemiology, Biomarkers, and Prevention, the journal has published
three large prospective studies: Cancer Prevention Study II Nutrition Cohort (1), California …

To compare the effect of statin use in relation to castration-resistant prostate cancer (CRPC)
treatment, we assessed the risk of ADT-treated PCa-patients to initiate CRPC treatment by …

PURPOSE:: Reports of the effect of treatment with statins on prostate cancer risk are
inconsistent. We performed a pilot study to assess the effect of statin treatment on a …

Background Recently, there has been renewed interest in the link between cholesterol and
prostate cancer. It has been previously reported that in vitro, prostate cancer cells lack sterol …

BACKGROUND Epidemiologic data suggest cholesterol‐lowering drugs may prevent the
progression of prostate cancer, but not the incidence of the disease. However, the …

The aim of this study was to analyze the relationship between statin use along with serum
cholesterol levels and prostate cancer (PCa) detection and aggressiveness. Statin users of …