Endoderm development is dependent on inductive signals from different structures in close
vicinity, including the notochord, lateral plate mesoderm and endothelial cells. Recently, we …

Early growth and differentiation of the pancreatic endoderm is regulated by soluble factors
from the pancreatic mesenchyme. Previously, we demonstrated that N-cadherin-deficient …

Understanding the tissue interactions that induce pancreatic progenitor cells from the
embryonic endoderm provides insights into congenital malformations, tissue repair, and …

To evaluate potential roles of nitric oxide (NO) in the regulation of the endothelial lineage
and neovascular processes (vasculogenesis and angiogenesis) we evaluated endothelial …

It is well established that many tissue‐derived factors are involved in blood vessel formation,
but evidence is now emerging that endothelial cells themselves represent a crucial source of …

Dorsal and ventral pancreatic bud development from the endoderm requires inductive
interactions with diverse mesodermal cell types and the action of transcription factors …

Recent molecular and genetic studies have provided new insights into the mechanisms by
which gut endoderm is specified to a pancreatic fate. However, the distinct inductive and …

We have recently reported the method by which embryonic stem (ES) cells were induced
into Pdx1‐expressing cells. To gain insights into the ES cell‐derived Pdx1‐expressing cells …

An unresolved question in vasculogenesis is how mammalian endothelial cells make
lumens in developing vessels. In this issue of Developmental Cell, Strilic et al. present a …

Pancreatic islet cells and neurons share common functions and similar ontogenies, but
originate in different germ layers. To determine whether ectoderm-derived cells contribute …