Immunoprofiling of Chlamydia trachomatis using whole-proteome microarrays generated by on-chip in situ expression

K Hufnagel, S Lueong, M Willhauck-Fleckenstein… - Scientific reports, 2018 - nature.com
Abstract Using Chlamydia trachomatis (Ct) as a complex model organism, we describe a
method to generate bacterial whole-proteome microarrays using cell-free, on-chip protein …

Identification of immunodominant antigens of Chlamydia trachomatis using proteome microarrays

DM Molina, S Pal, MA Kayala, A Teng, PJ Kim, P Baldi… - Vaccine, 2010 - Elsevier
Chlamydia trachomatis is the most common bacterial sexually transmitted pathogen in the
world. In order to control this infection there is an urgent need to formulate a vaccine …

Identification of Immunodominant Antigens by Probing a Whole Chlamydia trachomatis Open Reading Frame Proteome Microarray Using Sera from Immunized Mice

MI Cruz-Fisher, C Cheng, G Sun, S Pal… - Infection and …, 2011 - Am Soc Microbiol
Chlamydia trachomatis infections can lead to severe chronic complications, including
trachoma, ectopic pregnancy, and infertility. The only effective approach to disease control is …

Proteomic identification of immunodominant chlamydial antigens in a mouse model

A Teng, MI Cruz-Fisher, C Cheng, S Pal, G Sun… - Journal of …, 2012 - Elsevier
Chlamydia trachomatis is the most common bacterial sexually transmitted pathogen in the
world. To identify new vaccine candidates a protein microarray was constructed by …

A genome-wide profiling of the humoral immune response to Chlamydia trachomatis infection reveals vaccine candidate antigens expressed in humans

J Wang, Y Zhang, C Lu, L Lei, P Yu… - The Journal of …, 2010 - journals.aai.org
A whole genome scale proteome array consisting of 908 open reading frames encoded in
Chlamydia trachomatis genome and plasmid was used to profile anti-chlamydial Ab …

Chlamydia trachomatis Whole-Proteome Microarray Analysis of The Netherlands Chlamydia Cohort Study

K Hufnagel, B Hoenderboom, C Harmel, JK Rohland… - Microorganisms, 2019 - mdpi.com
Chlamydia trachomatis (Ct) whole-proteome microarrays were utilized to identify antibody
patterns associated with infection; pelvic inflammatory disease (PID), tubal factor infertility …

A novel synthetic peptide microarray assay detects Chlamydia species-specific antibodies in animal and human sera

K Sachse, KS Rahman, C Schnee, E Müller… - Scientific reports, 2018 - nature.com
Serological analysis of Chlamydia (C.) spp. infections is still mainly based on micro-
immunofluorescence and ELISA. To overcome the limitations of conventional serology, we …

Comparative proteome analysis of Chlamydia trachomatis serovar A, D and L2

AC Shaw, K Gevaert, H Demol, B Hoorelbeke… - …, 2002 - Wiley Online Library
Chlamydia trachomatis represents a group of human pathogenic obligate intracellular and
gram‐negative bacteria. The genome of C. trachomatis D comprises 894 open reading …

Rapid detection and strain typing of Chlamydia trachomatis using a highly multiplexed microfluidic PCR assay

RS Turingan, L Kaplun, G Krautz-Peterson… - PLoS …, 2017 - journals.plos.org
Nucleic acid amplification tests (NAATs) are recommended by the CDC for detection of
Chlamydia trachomatis (Ct) urogenital infections. Current commercial NAATs require …

Profiling of Human Antibody Responses to Chlamydia trachomatis Urogenital Tract Infection Using Microplates Arrayed with 156 Chlamydial Fusion Proteins

J Sharma, Y Zhong, F Dong, JM Piper… - Infection and …, 2006 - Am Soc Microbiol
The available chlamydial genome sequences have made it possible to comprehensively
analyze host responses to all chlamydial proteins, which is essential for further …