Genome-wide association of the laboratory-based nicotine metabolite ratio in three ancestries
JW Baurley, CK Edlund, CI Pardamean… - Nicotine & tobacco …, 2016 - academic.oup.com
Introduction: Metabolic enzyme variation and other patient and environmental characteristics
influence smoking behaviors, treatment success, and risk of related disease. Population …
influence smoking behaviors, treatment success, and risk of related disease. Population …
Analyses of nicotine metabolism biomarker genetics stratified by sex in African and European Americans
Nicotine is inactivated by the polymorphic CYP2A6 enzyme to cotinine and then to 3′
hydroxycotinine. The Nicotine Metabolite Ratio (NMR; 3′ hydroxycotinine/cotinine) is a …
hydroxycotinine. The Nicotine Metabolite Ratio (NMR; 3′ hydroxycotinine/cotinine) is a …
Genome‐wide association study of a nicotine metabolism biomarker in African American smokers: impact of chromosome 19 genetic influences
Background and aims The activity of CYP2A6, the major nicotine‐inactivating enzyme, is
measurable in smokers using the nicotine metabolite ratio (NMR; 3′ hydroxycotinine …
measurable in smokers using the nicotine metabolite ratio (NMR; 3′ hydroxycotinine …
Genome-wide association meta-analysis of nicotine metabolism and cigarette consumption measures in smokers of European descent
J Buchwald, MJ Chenoweth, T Palviainen, G Zhu… - Molecular …, 2021 - nature.com
Smoking behaviors, including amount smoked, smoking cessation, and tobacco-related
diseases, are altered by the rate of nicotine clearance. Nicotine clearance can be estimated …
diseases, are altered by the rate of nicotine clearance. Nicotine clearance can be estimated …
Transferability of ancestry‐specific and cross‐ancestry CYP2A6 activity genetic risk scores in African and European Populations
A El‐Boraie, MJ Chenoweth, JG Pouget… - Clinical …, 2021 - Wiley Online Library
The Nicotine Metabolite Ratio (NMR; 3‐hydroxycotinine/cotinine), a highly heritable index of
nicotine metabolic inactivation by the CYP2A6 enzyme, is associated with numerous …
nicotine metabolic inactivation by the CYP2A6 enzyme, is associated with numerous …
Multiethnic prediction of nicotine biomarkers and association with nicotine dependence
Introduction The nicotine metabolite ratio and nicotine equivalents are measures of
metabolism rate and intake. Genome-wide prediction of these nicotine biomarkers in …
metabolism rate and intake. Genome-wide prediction of these nicotine biomarkers in …
A genome-wide association study of a biomarker of nicotine metabolism
A Loukola, J Buchwald, R Gupta, T Palviainen… - PLoS …, 2015 - journals.plos.org
Individuals with fast nicotine metabolism typically smoke more and thus have a greater risk
for smoking-induced diseases. Further, the efficacy of smoking cessation pharmacotherapy …
for smoking-induced diseases. Further, the efficacy of smoking cessation pharmacotherapy …
Evaluation of a weighted genetic risk score for the prediction of biomarkers of CYP2A6 activity
A El‐Boraie, T Taghavi, MJ Chenoweth… - Addiction …, 2020 - Wiley Online Library
The nicotine metabolite ratio (NMR; 3‐hydroxycotinine/cotinine) is an index of CYP2A6
activity. CYP2A6 is responsible for nicotine's metabolic inactivation and variation in the …
activity. CYP2A6 is responsible for nicotine's metabolic inactivation and variation in the …
Variation in CYP2A6 and nicotine metabolism among two American Indian tribal groups differing in smoking patterns and risk for tobacco-related cancer
JA Tanner, JA Henderson, D Buchwald… - Pharmacogenetics …, 2017 - journals.lww.com
Objective The Northern Plains (NP) and Southwest (SW) American Indian populations differ
in their smoking patterns and lung cancer incidence. We aimed to compare CYP2A6 genetic …
in their smoking patterns and lung cancer incidence. We aimed to compare CYP2A6 genetic …
Novel CYP2A6 diplotypes identified through next-generation sequencing are associated with in-vitro and in-vivo nicotine metabolism
Objectives Smoking patterns and cessation rates vary widely across smokers and can be
influenced by variation in rates of nicotine metabolism [ie cytochrome P450 2A6 (CYP2A6) …
influenced by variation in rates of nicotine metabolism [ie cytochrome P450 2A6 (CYP2A6) …