The pharmacokinetics of 400 mg of ciprofloxacin given intravenously (iv) every 8 h (q8h) in
severely septic adults was documented in a multidisciplinary, tertiary referral intensive care …

Seventy-four acutely ill patients were treated with intravenous ciprofloxacin at dosages
ranging between 200 mg every 12 h and 400 mg every 8 h. A population pharmacokinetic …

We injected multiple doses of intravenous ciprofloxacin over 10 minutes every 12 hours for 1
week to nine healthy subjects, while three other subjects received placebo. Ciprofloxacin …

PURPOSE: Optimal dosing of antibiotics is important for efficacy and avoidance of
resistance. Fluoroquinolones are frequently used to treat severe infections in critically ill …

We administered multiple doses of ciprofloxacin intravenously over 30 min every 12 h for 1
week to nine healthy volunteers. Three volunteers received a placebo (vehicle) …

The objective of this study was to evaluate the properties of ciprofloxacin in intensive care
patients using a population approach. Seventy patients received ciprofloxacin. On Day 1 …

The dosing of ciprofloxacin in renal impairment has been debated since the late 1980s
(Fillastre et al., 1987). Basing their recommendations on a single iv dose of ciprofloxacin 100 …

Serum concentrations of ciprofloxacin were reviewed in 22 patients given ciprofloxacin 400
mg intravenously 12 hourly for severe infection. No dosage modifications were made in …

Ciprofloxacin was administered to 12 healthy male volunteers at doses of 300 and 400 mg
intravenously (iv) and 500 and 750 mg orally in a randomized, double-blind, single-dose …

Objective: To determine the pharmacokinetic profile of ciprofloxacin 20 mg/kg per day (10
mg/kg administered intravenously 12 hourly) in paediatric patients with severe sepsis …