PI3K/AKT signaling mediated by G protein‑coupled receptors is involved in neurodegenerative Parkinson's disease

N Nakano, S Matsuda, M Ichimura… - International …, 2017 - spandidos-publications.com
Parkinson's disease (PD) is a common progressive and multifactorial neurodegenerative
disease, characterized by the loss of midbrain dopaminergic neurons. Numerous …

[HTML][HTML] The PI3K-AKT pathway: A plausible therapeutic target in Parkinson's disease

A Goyal, A Agrawal, A Verma, N Dubey - Experimental and Molecular …, 2023 - Elsevier
Parkinson's disease is a common progressive and multifactorial neurodegenerative disease,
characterized by the loss of midbrain dopaminergic neurons. Numerous pathological …

[HTML][HTML] p38 MAPK and PI3K/AKT signalling cascades inParkinson's disease

SK Jha, NK Jha, R Kar, RK Ambasta… - International journal of …, 2015 - ncbi.nlm.nih.gov
Parkinson's disease (PD) is a chronic neurodegenerative condition which has the second
largest incidence rate among all other neurodegenerative disorders barring Alzheimer's …

Neuroprotection of GLP-1/GIP receptor agonist via inhibition of mitochondrial stress by AKT/JNK pathway in a Parkinson's disease model

T Li, L Tu, R Gu, XL Yang, XJ Liu, GP Zhang, Q Wang… - Life sciences, 2020 - Elsevier
Objectives To investigate the effect of glucagon-like peptide-1 (GLP-1) receptor and glucose
dependent insulinotrophic polypeptide (GIP) receptor dual agonist DA-JC4 on alleviating …

Role of mitogen activated protein kinase signaling in Parkinson's disease

A Bohush, G Niewiadomska, A Filipek - International journal of molecular …, 2018 - mdpi.com
Parkinson's disease (PD) is a neurodegenerative disorder caused by insufficient dopamine
production due to the loss of 50% to 70% of dopaminergic neurons. A shortage of dopamine …

Neuroprotective and therapeutic strategies against Parkinson's disease: recent perspectives

S Sarkar, J Raymick, S Imam - International journal of molecular sciences, 2016 - mdpi.com
Parkinsonism is a progressive motor disease that affects 1.5 million Americans and is the
second most common neurodegenerative disease after Alzheimer's. Typical …

Targeting G protein-coupled receptors in the treatment of Parkinson's disease

J Jones-Tabah - Journal of Molecular Biology, 2023 - Elsevier
Parkinson's disease (PD) is a progressive neurodegenerative disease characterized in part
by the deterioration of dopaminergic neurons which leads to motor impairment. Although …

Neuroprotective effects of a GIP analogue in the MPTP Parkinson's disease mouse model

Y Li, WZ Liu, L Li, C Hölscher - Neuropharmacology, 2016 - Elsevier
Parkinson's disease (PD) is a chronic neurodegenerative disease, and there is no cure for it
at present. Recent research has indicated a link between type 2 diabetes mellitus (T2DM) …

PI3K/AKT signal pathway: a target of natural products in the prevention and treatment of Alzheimer's disease and Parkinson's disease

HZ Long, Y Cheng, ZW Zhou, HY Luo… - Frontiers in …, 2021 - frontiersin.org
Alzheimer's disease (AD) and Parkinson's disease (PD) are two typical neurodegenerative
diseases that increased with aging. With the emergence of aging population, the health …

G-protein coupled receptor, PI3K and Rho signaling pathways regulate the cascades of Tau and amyloid-β in Alzheimer's disease

SE Desale, H Chidambaram, S Chinnathambi - Molecular Biomedicine, 2021 - Springer
Alzheimer's disease is a progressive neurodegenerative disease characterized by the
presence of amyloid-β plaques in the extracellular environment and aggregates of Tau …