Site-specific protein modification techniques have led to breakthroughs across diverse
fields, such as cell imaging, proteomics, biomaterials, and pharmaceutical protein and …

The spatial alignment of functional groups is a central aspect of most catalytic processes.
Protein scaffolds with their exceptional molecular recognition properties have evolved into …

The late‐stage functionalization of peptides and proteins holds significant promise for drug
discovery and facilitates bioorthogonal chemistry. This selective functionalization leads to …

Chemical reactions can be performed to covalently modify specific residues in proteins.
When applied to native enzymes, these chemical modifications can greatly expand the …

The rising demand for regioselective protein modifications in chemical biology and
pharmaceutical manufacturing has fueled efforts to develop diverse techniques that …

Amide bond synthesis is ranked as the second most important challenge in key green
chemistry research areas identified by the ACS Green Chemistry Institute. While developing …

Direct peptide and protein activation is a challenging transformation because of the
stabilizing effect of the amide group. While enzymes can be considered as prototypical …

In the past decade, numerous chemical technologies have been developed to allow the site-
specific post-translational modification of proteins. Traditionally covalent chemical protein …

Proteins constitute the majority of nature's worker biomolecules. Designed for specific
functions, complex tertiary structures make proteins ideal candidates for analysing natural …

The site-selective editing of peptides and proteins through backbone modification holds
significant promise in the realms of therapeutic and diagnostic agents, drug development …