Pulmonary fibrosis and emphysema are chronic lung diseases characterized by a
progressive decline in lung function, resulting in significant morbidity and mortality. A …

Abstract Purpose of Review Lung fibrosis is currently thought to stem from an aberrant
wound healing response after recurring (micro) injuries in the lung epithelium, together with …

Pulmonary fibrosis represents the sequelae of a variety of acute and chronic lung injuries of
known and unknown etiologies. Tissue specimens obtained from patients with pulmonary …

Lung epithelial cells have emerged as a frequent target of injury, a driver of normal repair,
and a key element in the pathobiology of fibrotic lung diseases. An important aspect of …

The extracellular matrix (ECM) is dynamically tuned to optimize physiological function. Its
major properties, including composition and mechanics, profoundly influence cell biology …

Idiopathic pulmonary fibrosis (IPF) is a chronic fibrotic disease of the lung that is marked by
progressive decline in pulmonary function and ultimately respiratory failure. Genetic and …

Pulmonary fibrosis is a progressive and ultimately fatal condition, characterized
pathologically by mesenchymal cell proliferation in the lung, expansion of the extracellular …

Introduction: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung
disease characterized by irreversible fibrosis. Current disease pathogenesis assumes an …

Lung fibrosis is a recognized feature of many chronic lung diseases and is central to the
pathogenesis of idiopathic pulmonary fibrosis, a disease that carries a prognosis worse than …

A set of lung diseases share the tendency for the development of progressive fibrosis
ultimately leading to respiratory failure. This review examines the common pathogenetic …