Aim: Genome-wide association studies have identified several novel loci associated with
serum uric acid concentrations in individuals of European descent. In the current study, we …

Background Uric acid (UA) is a complex phenotype influenced by both genetic and
environmental factors as well as their interactions. Current genome-wide association studies …

Genome-wide association studies identified that SLC2A9 (GLUT9) gene polymorphisms
were associated with serum uric acid (SUA) levels. Among the Japanese, a C/T …

Elevated serum uric acid levels cause gout and are a risk factor for cardiovascular disease
and diabetes. To investigate the polygenetic basis of serum uric acid levels, we conducted a …

Genome‑wide association studies identified that a series of genes, including solute carrier
family (SLC) 2 member 9 (SLC2A9), SLC 22 member 12 (SLC22A12) and ATP‑binding …

BACKGROUND AND OBJECT: It has been suggested that the SLC22A12 gene
polymorphism may be involved in the mechanism of renal urate handling. The purpose of …

Abstract Background Although SLC22A12 258X allele was found among those with
hypouricemia, it was unknown that serum uric acid distribution among those with SLC22A12 …

Prolonged hyperuricemia is a cause of gout and an independent risk factor for chronic
health conditions including diabetes and chronic kidney diseases. Genome-wide …

Background Elevated serum uric acid concentration is an independent risk factor and
predictor of type 2 diabetes (T2D). Whether the uric acid-associated genes have an impact …

Uric acid (UA) is the final catabolic product of purine metabolism and elevated levels are
associated with diabetes and cardiovascular disease. A recent meta-analysis of genome …