Scorpion venom represents a tremendous hitherto unexplored resource for understanding
ion channels. BmK86 is a novel K+-channel toxin gene isolated from a cDNA library of …

Scorpion venom contains many small polypeptide toxins, which can modulate Na+, K+, Cl−,
and Ca2+ ion–channel conductance in the cell membrane. A full‐length cDNA sequence …

The availability of a large variety of specific blockers, which inhibit different K+ currents,
would help to elucidate their differences in physiological function. Short peptide toxins …

Scorpion toxins are invaluable pharmacological tools for studying ion channels and
potential drugs for channelopathies. The long-chain toxins from scorpion venom with four …

A new toxin, named HsTX1, has been identified in the venom of Heterometrus spinnifer
(Scorpionidae), on the basis of its ability to block the rat Kv1. 3 channels expressed in …

Three novel toxins belonging to the scorpion K+ channel-inhibitor family were purified to
homogeneity from the venom of the Chinese scorpion Buthus martensi. They have been …

Scorpion venom is composed of a large repertoire of biologically active polypeptides.
However, most of these peptides remain to be identified and characterized. In this paper, we …

A full-length cDNA encoding the precursor of a K+ channel toxin (BmTX2) was first isolated
from a venom-gland cDNA library of the Chinese scorpion Buthus martensii Karsch. The …

A new scorpion toxin (3751.8 Da) was isolated from the Buthus martensi venom, sequenced
and chemically synthesized (sBmTX3). The A-type current of striatum neurons in culture …

Most of scorpion toxins affecting voltage-gated K+ channels (KTxs) contain a functional dyad
composed of a lysine and an aromatic amino acid separated by a suitable distance. By …