Rationale: Continuous infusion of β-lactam antibiotics may improve outcomes because of
time-dependent antibacterial activity compared with intermittent dosing. Objectives: To …

Rationale: Optimization of β-lactam antibiotic dosing for critically ill patients is an intervention
that may improve outcomes in severe sepsis. Objectives: In this individual patient data meta …

Purpose This study aims to determine if continuous infusion (CI) is associated with better
clinical and pharmacokinetic/pharmacodynamic (PK/PD) outcomes compared to intermittent …

Background. Beta-lactam antibiotics are a commonly used treatment for severe sepsis, with
intermittent bolus dosing standard therapy, despite a strong theoretical rationale for …

Background and rationale: β-Lactam antibiotics display a time-dependent mechanism of
action, with evidence suggesting improved outcomes when administering these drugs via …

Background The prolonged β-lactam infusion strategy has emerged as the standard
treatment for sepsis or septic shock despite its unknown efficacy. This study aimed to assess …

There is controversy over whether traditional intermittent bolus dosing or continuous infusion
of beta-lactam antibiotics is preferable in critically ill patients. No significant difference …

Continuous infusion of β-lactam antibiotics has been widely promoted to optimise their time-
dependent activity. Increasing evidence is emerging suggesting potential benefits in patient …

The clinical advantages of prolonged (extended/continuous) infusion remain controversial.
Previous studies and reviews have failed to show consistent clinical benefits of extending …

Objective: The clinical benefits of extended infusion or continuous infusion of β-lactam
antibiotics remain controversial. We systematically reviewed the literature to determine …