Experimental autoimmune encephalomyelitis (EAE) is a CD4+ Th1 T cell-mediated disease
of the CNS, used to study certain aspects of multiple sclerosis. CXCR3, the receptor for …

The chemokine receptor CXCR3 promotes the trafficking of activated T and NK cells in
response to three ligands, CXCL9, CXCL10, and CXCL11. Although these chemokines are …

Drugs that block leukocyte trafficking ameliorate multiple sclerosis (MS). Occurrences of
opportunistic infection, however, highlight the need for novel drugs that modulate more …

Experimental autoimmune encephalomyelitis (EAE) is a CD4+ Th1-mediated demyelinating
disease of the CNS that serves as a model for multiple sclerosis. A critical event in the …

Cases of progressive multifocal leukoencephalopathy can occur in patients treated with the
B cell depleting anti-CD20 antibody, rituximab, highlighting the importance of B cell …

Experimental autoimmune encephalomyelitis (EAE) is a Tcell-mediated autoimmune
disease of the CNS that is widely used as an animal model of multiple sclerosis. In this …

Autoreactive T‐cell infiltration into the CNS is critical in MS and EAE. The chemokine
receptor CXCR3 and its ligands are implicated in MS and mouse EAE, but the contribution of …

Multiple sclerosis (MS) is an autoimmune disease of the CNS characterized by disruption of
the blood-brain barrier (BBB). This breach in CNS immune privilege allows undeterred …

Chemokines regulate lymphocyte trafficking under physiologic and pathologic conditions. In
this study, we have investigated the role of CXCR3 and CXCR4 in the activation of T …

A single G protein–coupled receptor (GPCR) can activate multiple signaling cascades
based on the binding of different ligands. The biological relevance of this feature in immune …