The movement of lymphocytes from the microvasculature into the central nervous system
(CNS) parenchyma is an essential step in the pathogenesis of a variety of infectious and …

The ELR+ CXC chemokines CXCL1 and CXCL2 are up-regulated in the central nervous
system (CNS) during multiple sclerosis (MS) and its animal model, experimental …

T-cell accumulation in the central nervous system (CNS) is considered crucial to the
pathogenesis of multiple sclerosis (MS). We found that the majority of T cells within the …

Abstract IFN-γ-inducible protein 10/CXCL10 is a chemokine associated with type 1 T cell
responses, regulating the migration of activated T cells through binding to the CXCR3 …

In multiple sclerosis (MS) and its animal model, experimental autoimmune
encephalomyelitis (EAE), autoaggressive T cells traffic into the CNS and induce disease …

The JAK/STAT pathway is critical for development, regulation, and termination of immune
responses, and dysregulation of the JAK/STAT pathway, that is, hyperactivation, has …

Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis,
a chronic inflammatory and demyelinating disease of the CNS. Albino Oxford (AO) rats are …

Microbial infections of the central nervous system (CNS) are often associated with local
accumulation of antibody (Ab)-secreting cells (ASC). By providing a source of Ab at the site …

Multiple sclerosis (MS) is characterized by central nervous system (CNS) inflammation,
demyelination, and axonal degeneration. CXCL10 (IP-10), a chemokine for CXCR3+ T cells …

Experimental autoimmune encephalomyelitis (EAE) is a T cell–mediated autoimmune
disease of the central nervous system induced by antigen-specific effector Th17 and Th1 …