The chemokine, CXC motif ligand 13 (CXCL13), is constitutively expressed in lymphoid
organs and controls the recruitment and compartmentalization of lymphocytes and antigen …

Background CCR2 plays a key role in regulating monocyte trafficking to sites of inflammation
and therefore has been the focus of much interest as a target for inflammatory disease …

Leukocyte trafficking to the central nervous system (CNS), regulated in part by chemokines,
determines severity of the demyelinating diseases multiple sclerosis (MS) and experimental …

T cell infiltration into the CNS is a significant underlying pathogenesis in autoimmune
inflammatory demyelinating diseases. Several lines of evidence suggest that glutamate …

Chemokines have emerged as important mediators of leukocyte recruitment to the CNS
across the normally restrictive blood–brain barrier (BBB). In the present study we …

Background Chemokines and chemokine receptors cooperate to promote immune cell
recruitment to the central nervous system (CNS). In this study, we investigated the roles of …

Structurally related chemotactic cytokines (chemokines) regulate cell trafficking through
interactions with 7-transmembrane domain, G protein-coupled receptors. Biased signaling …

Background and purpose: The C–C chemokine receptor CCR5, and the C–X–C chemokine
receptor CXCR3 are involved in the regulation of T cell‐mediated immune responses, and in …

Experimental autoimmune encephalomyelitis (EAE) is an inflammatory demyelinating
disease with similarities to multiple sclerosis (MS). It is induced in mice by the transfer of …

Dendritic cells (DCs) are pivotal for the development of experimental autoimmune
encephalomyelitis (EAE). However, the mechanisms by which they control disease remain …