What can platinum offer yet in the treatment of PS2 NSCLC patients? A systematic review and meta-analysis

G Bronte, C Rolfo, F Passiglia, S Rizzo… - Critical reviews in …, 2015 - Elsevier
Background Randomized phase III trials showed interesting, but conflicting results,
regarding the treatment of NSCLC, PS2 population. This meta-analysis aims to review all …

Dilemmas in Management: The Controversial Role of Chemotherapy in PS 2 Advanced NSCLC and the Potential Role of CT-2103 (Xyotax)

CJ Langer - The Oncologist, 2004 - academic.oup.com
Platinum-based chemotherapy improves long-term survival in patients with advanced non-
small cell lung cancer (NSCLC). Meta-analyses have demonstrated an improvement in …

Chemotherapy and quality of life in NSCLC PS 2 patients

N Helbekkmo, HH Strøm, SH Sundstrøm… - Acta …, 2009 - Taylor & Francis
Introduction. Nearly 40% of patients with advanced NSCLC are in performance status (PS)
2. These patients have a shorter life expectancy than PS 0/1 patients and they are …

[HTML][HTML] Chemotherapy of advanced NSCLC in special patient population

C Gridelli, P Maione, A Rossi, C Guerriero, C Ferrara… - Annals of …, 2006 - Elsevier
The elderly and patients with Performance Status (PS) of 2, constitute the so-called special
patient population. The tolerability of chemotherapy in this population is globally worse, and …

Treatment outcome in performance status 2 advanced NSCLC patients administered platinum-based combination chemotherapy

N Helbekkmo, U Aasebø, SH Sundstrøm… - Lung Cancer, 2008 - Elsevier
BACKGROUND: There is no consensus regarding chemotherapy to patients with advanced
NSCLC (ANSCLC) and performance status (PS) 2. Using data from a national multicenter …

Comparison of efficacy and safety of PD-1/PD-L1 combination therapy in first-line treatment of advanced NSCLC: an updated systematic review and network meta …

Y Yang, W Chen, L Dong, L Duan, P Gao - Clinical and Translational …, 2024 - Springer
Background The use of immune checkpoint inhibitors has led to an increase in randomized
controlled trials exploring various first-line combination treatment regimens. With the …

Analysis of prognostic factors in chemo-naive patients with advanced NSCLC and poor performance status (PS): Cox regression analysis of two phase III trials

M O'Brien, P Bonomi, C Langer, K O'Byrne… - Journal of Clinical …, 2006 - ascopubs.org
7113 Background: Two phase III trials in chemo-naïve PS2 patients with advanced NSCLC
compared paclitaxel poliglumex (PPX) to either gemcitabine or vinorelbine (STELLAR 4), or …

[HTML][HTML] Clinical Trial and Real-World Outcomes of Patients With Metastatic NSCLC in the Post-Platinum–Based Chemotherapy Failure Setting

YY Soon, W Furnback, J Kim, PY Chuang… - JTO Clinical and …, 2023 - Elsevier
Introduction A literature review was undertaken to identify clinical trials and real-world
studies of patients with stage IV NSCLC who had progressed on or after treatment with …

Platinum rechallenge in patients with advanced NSCLC: a pooled analysis

F Petrelli, A Coinu, M Cabiddu, M Ghilardi, M Ardine… - Lung Cancer, 2013 - Elsevier
Introduction The sole agents pemetrexed (PEM), docetaxel and anti-EGFR agents are
approved second-line therapies for non-small cell lung cancer (NSCLC) after failure with …

Multicentric retrospective analysis of platinum‐pemetrexed regimens as first‐line therapy in non‐squamous non‐small cell lung cancer patients: A “snapshot” from …

A Cortellini, E Gambale, K Cannita, D Brocco… - Thoracic …, 2018 - Wiley Online Library
Background The major challenge for treating non‐squamous (non‐Sq) non‐small cell lung
cancer (NSCLC) patients without actionable biomarkers is the actual selection of proper …