Serum response factor: master regulator of the actin cytoskeleton and contractile apparatus

JM Miano, X Long, K Fujiwara - American Journal of …, 2007 - journals.physiology.org
Serum response factor (SRF) is a highly conserved and widely expressed, single copy
transcription factor that theoretically binds up to 1,216 permutations of a 10-base pair cis …

Organization and myogenic restricted expression of the murine serum response factor gene: a role for autoregulation

NS Belaguli, LA Schildmeyer, RJ Schwartz - Journal of Biological Chemistry, 1997 - ASBMB
Serum response factor (SRF), a member of an ancient family of DNA-binding proteins, is
generally assumed to be a ubiquitous transcription factor involved in regulating growth factor …

Restricted inactivation of serum response factor to the cardiovascular system

JM Miano, N Ramanan, MA Georger… - Proceedings of the …, 2004 - National Acad Sciences
Serum response factor (SRF) directs programs of gene expression linked to growth and
muscle differentiation. To investigate the role of SRF in cardiovascular development, we …

Serum response factor: toggling between disparate programs of gene expression

JM Miano - Journal of molecular and cellular cardiology, 2003 - Elsevier
Serum response factor (SRF) is a widely expressed transcription factor involved in
orchestrating disparate programs of gene expression linked to muscle differentiation and …

Signal-regulated activation of serum response factor is mediated by changes in actin dynamics

A Sotiropoulos, D Gineitis, J Copeland, R Treisman - Cell, 1999 - cell.com
Serum response factor (SRF) regulates transcription of many serum-inducible and muscle-
specific genes. Using a functional screen, we identified LIM kinase-1 as a potent activator of …

[HTML][HTML] Role of serum response factor in the pathogenesis of disease

JM Miano - Laboratory investigation, 2010 - Elsevier
Serum response factor (SRF) is a ubiquitously expressed transcription factor that binds to a
DNA cis element known as the CArG box, which is found in the proximal regulatory regions …

Actin'together: serum response factor, its cofactors and the link to signal transduction

G Posern, R Treisman - Trends in cell biology, 2006 - cell.com
The vast diversity of cellular types and behaviours is mainly the result of combinatorial
interactions between a limited number of transcription factors and cellular signalling …

Requirement for serum response factor for skeletal muscle growth and maturation revealed by tissue-specific gene deletion in mice

S Li, MP Czubryt, J McAnally… - Proceedings of the …, 2005 - National Acad Sciences
Serum response factor (SRF) controls the transcription of muscle genes by recruiting a
variety of partner proteins, including members of the myocardin family of transcriptional …

Dominant negative murine serum response factor: alternative splicing within the activation domain inhibits transactivation of serum response factor binding targets

NS Belaguli, W Zhou, THT Trinh… - … and cellular biology, 1999 - Am Soc Microbiol
Primary transcripts encoding the MADS box superfamily of proteins, such as MEF2 in
animals and ZEMa in plants, are alternatively spliced, producing several isoformic species …

Differential usage of signal transduction pathways defines two types of serum response factor target gene

D Gineitis, R Treisman - Journal of Biological Chemistry, 2001 - ASBMB
Activation of the transcription factor serum response factor (SRF) is dependent on Rho-
controlled changes in actin dynamics. We used pathway-specific inhibitors to compare the …