Staphylococcus aureus is the most common cause of skin and soft tissue infections, and
rapidly emerging antibiotic-resistant strains are creating a serious public health concern. If …

Staphylococcus aureus causes most infections of human skin and soft tissue and is a major
infectious cause of mortality. Host defense mechanisms against S. aureus are incompletely …

Th17 cells are a distinct lineage of effector CD4+ T cells characterized by their production of
interleukin (IL)-17. We demonstrate that Th17 cells also expressed IL-22, an IL-10 family …

T cell cytokines contribute to immunity against Staphylococcus aureus, but the predominant
T cell subsets involved are unclear. In an S. aureus skin infection mouse model, we found …

Staphylococcus aureus colonization contributes to skin inflammation in diseases such as
atopic dermatitis, but the signaling pathways involved are unclear. Herein, epicutaneous S …

Abstract Interleukin (IL)-17A is a pro-inflammatory cytokine in mice and humans. It is
recognized as a key factor for the protection of mice against various pathogens, but it also …

IL-23 plays an important role in autoimmune tissue inflammation and induces the generation
of not fully characterized effector cells that mediate protection against pathogens. In this …

Complications arising from cutaneous and soft tissue infections with Staphylococcus aureus
are a major clinical problem owing to the high incidence of these infections and the …

IL-23 and Th17 cells play important roles in host defense against systemic infections with
extracellular bacteria and fungi, although their roles in immunity against localized skin …

Although many microbial infections elicit an adaptive immune response that can protect
against reinfection, it is generally thought that Staphylococcus aureus infections fail to …