Effective population size does not predict codon usage bias in mammals
MD Kessler, MD Dean - Ecology and evolution, 2014 - Wiley Online Library
Synonymous codons are not used at equal frequency throughout the genome, a
phenomenon termed codon usage bias (CUB). It is often assumed that interspecific variation …
phenomenon termed codon usage bias (CUB). It is often assumed that interspecific variation …
Strong selection at the level of codon usage bias: evidence against the Li-Bulmer model
Codon usage bias (CUB), where certain codons are used more frequently than expected by
chance, is a ubiquitous phenomenon and occurs across the tree of life. The dominant …
chance, is a ubiquitous phenomenon and occurs across the tree of life. The dominant …
Codon usage bias in animals: disentangling the effects of natural selection, effective population size, and GC-biased gene conversion
Selection on codon usage bias is well documented in a number of microorganisms. Whether
codon usage is also generally shaped by natural selection in large organisms, despite their …
codon usage is also generally shaped by natural selection in large organisms, despite their …
Pervasive Strong Selection at the Level of Codon Usage Bias in Drosophila melanogaster
Codon usage bias (CUB), where certain codons are used more frequently than expected by
chance, is a ubiquitous phenomenon and occurs across the tree of life. The dominant …
chance, is a ubiquitous phenomenon and occurs across the tree of life. The dominant …
Studies on the origin and evolution of codon bias
JC Biro - arXiv preprint arXiv:0807.3901, 2008 - arxiv.org
Background: There is a 3-fold redundancy in the Genetic Code; most amino acids are
encoded by more than one codon. These synonymous codons are not used equally; there is …
encoded by more than one codon. These synonymous codons are not used equally; there is …
Codon usage bias covaries with expression breadth and the rate of synonymous evolution in humans, but this is not evidence for selection
AO Urrutia, LD Hurst - Genetics, 2001 - academic.oup.com
In numerous species, from bacteria to Drosophila, evidence suggests that selection acts
even on synonymous codon usage: codon bias is greater in more abundantly expressed …
even on synonymous codon usage: codon bias is greater in more abundantly expressed …
Accounting for background nucleotide composition when measuring codon usage bias
JA Novembre - Molecular biology and evolution, 2002 - academic.oup.com
The phenomenon of codon usage bias has been important in the study of evolution because
it provides examples of weak selection working at the molecular level. During the last two …
it provides examples of weak selection working at the molecular level. During the last two …
Selection on codon bias
R Hershberg, DA Petrov - Annual review of genetics, 2008 - annualreviews.org
In a wide variety of organisms, synonymous codons are used with different frequencies, a
phenomenon known as codon bias. Population genetic studies have shown that …
phenomenon known as codon bias. Population genetic studies have shown that …
Vertebrate codon bias indicates a highly GC-rich ancestral genome
M Nabiyouni, A Prakash, A Fedorov - Gene, 2013 - Elsevier
Two factors are thought to have contributed to the origin of codon usage bias in eukaryotes:
1) genome-wide mutational forces that shape overall GC-content and create context …
1) genome-wide mutational forces that shape overall GC-content and create context …
Intragenomic variation in non-adaptive nucleotide biases causes underestimation of selection on synonymous codon usage
Patterns of non-uniform usage of synonymous codons vary across genes in an organism
and between species across all domains of life. This codon usage bias (CUB) is due to a …
and between species across all domains of life. This codon usage bias (CUB) is due to a …