The discovery of the rapid antidepressant effects of ketamine has arguably been the most
important advance in depression treatment. Recently, it was reported that repeated long …

Aim Major depressive disorder is a common and debilitating condition with substantial
economic impact. Treatment options, although effective, are aimed at relieving the symptoms …

Ketamine produces a rapid antidepressant response in patients with major depressive
disorder (MDD), but the underlying mechanisms appear multifaceted. One hypothesis …

Major depressive disorder affects millions of people and leads to debilitating symptoms.
Although conventional antidepressants have been available and are often beneficial, they …

Background Augmentation therapies may be effective strategies to potentiate the ketamine's
actions with lower potential for knock-on effects. Thus, this study investigated the ability of …

A debilitating mental disorder, major depressive disorder is a leading cause of global
disease burden. Existing antidepressant drugs are not adequate for the majority of …

Depression is associated both with a reduced size of brain regions regulating mood and
cognition, including the prefrontal cortex and the hippocampus, and decreased neuronal …

Ketamine is an open channel blocker of ionotropic glutamatergic N-Methyl-D-Aspartate
(NMDA) receptors. The discovery of its rapid antidepressant effects in patients with …

Currently available medications have significant limitations, most notably low response rate
and time lag for treatment response. Recent clinical studies have demonstrated that …

Although the molecular mechanism is not clear, the clinically tested drug ketamine has rapid
antidepressant action that does not require the multiple weeks of treatment needed for other …