An efficient synthetic route to a suitably protected β-selenol-phenylalanine derivative from
commercially available Garner's aldehyde is described. The incorporation of this building …

The synthesis of suitably protected β-selenophenylalanine and β-selenoleucine amino acids
was accomplished from Garner's aldehyde as a common starting point. These selenoamino …

The convergent assembly of peptide fragments by native chemical ligation has
revolutionized the way in which proteins can be accessed by chemical synthesis. A variation …

We describe an unprecedented reaction between peptide selenoesters and peptide dimers
bearing N-terminal selenocystine that proceeds in aqueous buffer to afford native amide …

The synthesis of proteins by native chemical ligation greatly enhances the application of
chemistry to complex molecules such as proteins. The essential building blocks for this …

Main observation and conclusion Selenoesters are useful substitutes for traditional
thioesters in protein ligation chemistry due to their high reactivity in the trans‐thio …

The use of native chemical ligation at selenocysteine (Sec) residues with peptide thioesters
and additive‐free selenocystine ligation with peptides bearing phenyl selenoesters, in …

Selenium variation on a cysteine theme: Selenocysteine (Sec) has been employed in a
number of chemoselective ligations. Sec can be used for native chemical and expressed …

Chemoselective peptide ligation methods have provided synthetic access to numerous
proteins, including those bearing native post-translational modifications and unnatural …

A series of non‐natural selenium‐containing amino acid derivatives and peptides have
been synthesized, in a flexible and modular strategy. The peptide coupling reaction between …