The nuclear lamina is a filamentous structure composed of lamins that supports the inner
nuclear membrane. Several integral membrane proteins including emerin, LBR, LAP1 and …

Lamins and other nuclear envelope proteins organize nuclear architecture through structural
attachments that vary dynamically during the cell cycle and cell differentiation. Genetic …

Nuclear lamin A and C alleles that are linked to three distinct human diseases have been
expressed both in HeLa cells and in fibroblasts derived from Lmna null mice. Point …

Nuclear lamins were originally described as the main constituents of the nuclear lamina, a
filamentous meshwork closely associated with the inner nuclear membrane. However, within …

In the past decade, the inner nuclear membrane has become a focus of research on
inherited diseases. A heterogeneous group of genetic disorders known as laminopathies …

The nuclear lamina is a protein meshwork lining the nucleoplasmic face of the inner nuclear
membrane and represents an important determinant of interphase nuclear architecture. Its …

In the past decade, a wide range of fascinating monogenic diseases have been linked to
mutations in the LMNA gene, which encodes the A-type nuclear lamins, intermediate …

Nuclear lamins are intermediate filament proteins that polymerize to form the nuclear lamina
on the inner aspect of the inner nuclear membrane. Long known to be essential for …

LMNA, the gene encoding A-type lamins (Bonne et al., opment, differentiation, and normal
cell function. Some 2000). These diseases took cell biologists by surprise, signals trigger …

Nuclear lamins form a fibrous nucleoskeletal network of intermediate‐sized filaments that
underlies the inner nuclear membrane. It associates with this membrane through …