Modification of proteins by metabolites in immunity

C Diskin, TAJ Ryan, LAJ O'neill - Immunity, 2021 - cell.com
Immunometabolism has emerged as a key focus for immunologists, with metabolic change
in immune cells becoming as important a determinant for specific immune effector …

A guide to immunometabolism for immunologists

LAJ O'Neill, RJ Kishton, J Rathmell - Nature reviews immunology, 2016 - nature.com
In recent years a substantial number of findings have been made in the area of
immunometabolism, by which we mean the changes in intracellular metabolic pathways in …

Immunometabolism: an overview and therapeutic prospects in autoimmune diseases

C Stathopoulou, D Nikoleri, G Bertsias - Immunotherapy, 2019 - Taylor & Francis
Metabolism is a critical immune regulator under physiologic and pathologic conditions.
Culminating evidence has disentangled the contribution of distinct metabolic pathways …

Driving immunity: all roads lead to metabolism

EJ Pearce, EL Pearce - Nature Reviews Immunology, 2018 - nature.com
In 2017, studies of cellular metabolism broadly permeated immunological research.
Accumulating data support the view that understanding how metabolism regulates immune …

Metabolic modulation in macrophage effector function

C Diskin, EM Pålsson-McDermott - Frontiers in immunology, 2018 - frontiersin.org
Traditionally cellular respiration or metabolism has been viewed as catabolic and anabolic
pathways generating energy and biosynthetic precursors required for growth and general …

Metabolic regulation of immune responses

K Ganeshan, A Chawla - Annual review of immunology, 2014 - annualreviews.org
The immune system defends against pathogens and maintains tissue homeostasis for the
life of the organism. These diverse functions are bioenergetically expensive, requiring …

Targeting immunometabolism as an anti-inflammatory strategy

EM Pålsson-McDermott, LAJ O'Neill - Cell research, 2020 - nature.com
The growing field of immunometabolism has taught us how metabolic cellular reactions and
processes not only provide a means to generate ATP and biosynthetic precursors, but are …

Metabolic stress in the immune function of T cells, macrophages and dendritic cells

C Domblides, L Lartigue, B Faustin - Cells, 2018 - mdpi.com
Innate and adaptive immune cells from myeloid and lymphoid lineages resolve host
infection or cell stress by mounting an appropriate and durable immune response. Upon …

Immunometabolism: cellular metabolism turns immune regulator

RM Loftus, DK Finlay - Journal of Biological Chemistry, 2016 - ASBMB
Immune cells are highly dynamic in terms of their growth, proliferation, and effector functions
as they respond to immunological challenges. Different immune cells can adopt distinct …

Unraveling the complex interplay between T cell metabolism and function

RI Klein Geltink, RL Kyle… - Annual review of …, 2018 - annualreviews.org
Metabolism drives function, on both an organismal and a cellular level. In T cell biology,
metabolic remodeling is intrinsically linked to cellular development, activation, function …