The neuropathological hallmark of Parkinson's disease (PD) is the preferential loss of
dopaminergic neurons in the substantia nigra and presence of Lewy bodies in the dying …

Parkinson's disease (PD) is neurodegenerative disease, featured by a loss of dopaminergic
neurons in the substantia nigra pars compacta (SNpc), characteristic motor symptoms and …

The relatively old, yet clinically used, drug methylene blue (MB) is known to possess
neuroprotective properties by reducing aggregated proteins, augmenting the antioxidant …

Rosmarinic acid (RA) is a naturally occurring polyphenolic compound found in various plant
families. We previously reported that RA exerted protective effects against 6 …

Oxidative stress and mitochondrial dysfunction are implicated in neuronal apoptosis
associated with Huntington's disease. Naringin is the flavanone present in grapefruit and …

Pinocembrin (PB), the most abundant flavonoid in propolis, has been proven to have
neuroprotective property against neurotoxicity in vivo and in vitro. Our recent study …

Endoplasmic reticulum stress (ERS) and mitochondrial dysfunctions are thought to be
involved in the dopaminergic neuronal death in Parkinson's disease (PD). In this study, we …

Neurons depend on mitochondria for homeostasis and survival, and thus, mitochondrial
dysfunction has been implicated in neurodegenerative diseases, including Parkinson's …

Although the pathogenic mechanisms of Parkinson's disease (PD) remain unclear, ample
empirical evidence suggests that oxidative stress is involved in the pathogenesis of this …

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by
intra neuronal proteinaceous cytoplasmic inclusions known as Lewy Bodies. A line of …