[HTML][HTML] Development of immunotherapy strategies targeting tumor microenvironment is fiercely ongoing

R Bai, J Cui - Frontiers in Immunology, 2022 - frontiersin.org
Tumor immune microenvironment is a very complex system that is influenced by a wide
range of factors; in this microenvironment, various immune cells, stromal cells, and cytokines …

[HTML][HTML] Re-education of the tumor microenvironment with targeted therapies and immunotherapies

SF Ngiow, A Young - Frontiers in immunology, 2020 - frontiersin.org
The clinical success of cancer immunotherapies targeting PD-1 and CTLA-4 has ignited a
substantial research effort to improve our understanding of tumor immunity. Recent studies …

Evolving strategies for tumor immunotherapy: enhancing the enhancer and suppressing the suppressor

Y Gu, Y Liu, X Cao - National Science Review, 2017 - academic.oup.com
Cancers develop complex and dynamic tissue microenvironments to support their sustained
growth, invasion and metastasis. For decades, rapid progress has been made in the cross …

[HTML][HTML] Role of the tumor immune microenvironment in tumor immunotherapy

C Zhou, Q Liu, Y Xiang, X Gou, W Li - Oncology Letters, 2022 - spandidos-publications.com
Tumor immunotherapy is considered to be a novel and promising therapy for tumors and it
has recently become a hot research topic. The clinical success of tumor immunotherapy has …

Immune microenvironment in tumor progression: characteristics and challenges for therapy

V Chew, HC Toh, JP Abastado - Journal of oncology, 2012 - Wiley Online Library
The tumor microenvironment plays a critical role in cancer development, progression, and
control. The molecular and cellular nature of the tumor immune microenvironment influences …

The influence of microenvironment on tumor immunotherapy

J Zhang, Z Shi, X Xu, Z Yu, J Mi - The FEBS journal, 2019 - Wiley Online Library
Tumor immunotherapy has achieved remarkable efficacy, with immune‐checkpoint
inhibitors as especially promising candidates for cancer therapy. However, some issues …

[HTML][HTML] The immunosuppressive tumor microenvironment and strategies to revert its immune regulatory milieu for cancer immunotherapy

M Ganjalikhani Hakemi, G Yanikkaya Demirel… - Frontiers in …, 2023 - frontiersin.org
Despite advancements in tumor immunotherapy, inconsistent therapeutic effects and
barriers impacting clinical outcomes highlight the need for a better understanding of the …

[HTML][HTML] Immunotherapy: reshape the tumor immune microenvironment

B Lv, Y Wang, D Ma, W Cheng, J Liu, T Yong… - Frontiers in …, 2022 - frontiersin.org
Tumor immune microenvironment (TIME) include tumor cells, immune cells, cytokines, etc.
The interactions between these components, which are divided into anti-tumor and pro …

[HTML][HTML] Present and future of cancer immunotherapy: A tumor microenvironmental perspective

Y Yu, J Cui - Oncology letters, 2018 - spandidos-publications.com
Modulation of the tumor microenvironment is becoming an increasingly popular research
topic in the field of immunotherapy, and studies regarding immune checkpoint blockades …

Immune modulation of the tumor microenvironment for enhancing cancer immunotherapy

C Devaud, LB John, JA Westwood, PK Darcy… - …, 2013 - Taylor & Francis
There is much promise in the use of immunotherapy for the treatment of cancer. Approaches
such as those using antibodies or adoptive cell transfer can mediate complete tumor …