The molecular recognition of two superantigens with class II major histocompatibility
complex molecules was simulated by using protein–protein docking. Superantigens studied …

Staphylococcal enterotoxin A (SEA) cross-links two class II major histocompatibility complex
(MHC) molecules and forms a multimeric assembly with T-cell receptors (TcRs). The X-ray …

We have used 600 MHz1H NMR spectroscopy data to determine the solution structure of a
31-residue domain of a murine class II major histocompatibility (MHC) protein. This domain, I …

The ability to accurately compute the atomic positions of substrate-bound ligands is central
to understanding biological recognition. Although substantial progress has been made in …

A novel algorithm is presented which models protein-protein interactions using surface
complementarity. The method is applied to antibody-antigen docking. A steric scoring …

Background: The tremendous increase in sequential and structural information is a
challenge for computer-assisted modelling to predict the binding modes of interacting …

Due to a paucity of studies that synthesize structural, energetic, and functional analyses of a
series of protein complexes representing distinct stages in an affinity maturation pathway …

Computer simulation of the conformations of short antigenic peptides (5–10 residues) either
free or bound to their receptor, the major histocompatibility complex (MHC)‐encoded …

Staphylococcal enterotoxins SEB and SEC3 and toxic shock syndrome toxin TSST‐1 act as
superantigens by overstimulating the human immune system and thereby compromise host …

In this article, we present a new technique for the rapid and precise docking of peptides to
MHC class I and class II receptors. Our docking procedure consists of three steps:(1) peptide …