Myeloid-derived suppressor cells: general characteristics and relevance to clinical management of pancreatic cancer

P Goedegebuure, JB Mitchem… - Current cancer drug …, 2011 - ingentaconnect.com
Recent studies describe a heterogeneous population of cells of the myeloid lineage, termed
myeloid derived suppressor cells (MDSC), which are observed with increased prevalence in …

Immunosuppressive cells and tumour microenvironment: focus on mesenchymal stem cells and myeloid derived suppressor cells

G Bianchi, G Borgonovo, V Pistoia… - … and histopathology, Vol …, 2011 - digitum.um.es
Tumours have been compared to unhealed wounds that produce large amounts of
inflammatory mediators, including cytokines, chemokines, and growth factors. These …

Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function

T Condamine, DI Gabrilovich - Trends in immunology, 2011 - cell.com
Myeloid-derived suppressor cells (MDSCs) are one of the main cell populations responsible
for regulating immune responses. MDSCs accumulate during tumor progression …

Reciprocal relationship between myeloid-derived suppressor cells and T cells

S Nagaraj, JI Youn, DI Gabrilovich - The Journal of Immunology, 2013 - journals.aai.org
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of myeloid cells that
play a major role in the regulation of immune responses in many pathological conditions …

Clinical perspectives on targeting of myeloid derived suppressor cells in the treatment of cancer

YG Najjar, JH Finke - Frontiers in oncology, 2013 - frontiersin.org
Tumors escape immune recognition by several mechanisms, and induction of myeloid
derived suppressor cells (MDSC) is thought to play a major role in tumor mediated immune …

Myeloid-derived suppressor cells in colorectal cancer

I Sieminska, J Baran - Frontiers in immunology, 2020 - frontiersin.org
Colorectal cancer (CRC) remains one of the most common malignancies diagnosed
worldwide. The pathogenesis of CRC is complex and involves, among others, accumulation …

Myeloid-derived suppressor cells and tumor escape from immune surveillance

V Umansky, C Blattner, V Fleming, X Hu… - Seminars in …, 2017 - Springer
Tumor progression is known to be supported by chronic inflammatory conditions developed
in the tumor microenvironment. It is characterized by the long-term secretion of various …

Functional characterization of human Cd33+ And Cd11b+ myeloid-derived suppressor cell subsets induced from peripheral blood mononuclear cells co-cultured …

MG Lechner, C Megiel, SM Russell, B Bingham… - Journal of translational …, 2011 - Springer
Background Tumor immune tolerance can derive from the recruitment of suppressor cell
populations, including myeloid-derived suppressor cells (MDSC). In cancer patients, MDSC …

Myeloid-derived suppressor cells: The green light for myeloma immune escape

E Malek, M de Lima, JJ Letterio, BG Kim, JH Finke… - Blood reviews, 2016 - Elsevier
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous, immature myeloid cell
population with the ability to suppress innate and adaptive immune responses that promote …

The immunosuppressive tumour network: myeloid‐derived suppressor cells, regulatory T cells and natural killer T cells

D Lindau, P Gielen, M Kroesen, P Wesseling… - …, 2013 - Wiley Online Library
Myeloid‐derived suppressor cells (MDSC) and regulatory T (Treg) cells are major
components of the immune suppressive tumour microenvironment (TME). Both cell types …