Primary immunodeficiencies are intrinsic defects in the immune system that result in a
predisposition to infection and are frequently accompanied by a propensity to autoimmunity …

We report the updated classification of primary immunodeficiencies (PIDs) compiled by the
Expert Committee of the International Union of Immunological Societies. In comparison to …

Primary immunodeficiencies include a variety of disorders that render patients more
susceptible to infections. If left untreated, these infections may be fatal. The disorders …

Activated PI3Kδ syndrome (APDS) is a rare inborn error of immunity (IEI) characterized
primarily by frequent infections, lymphoproliferation and autoimmunity. Since its initial …

Serum and intracytoplasmic cytokines are mandatory in host defense against microbes, but
also play a pivotal role in the pathogenesis of autoimmune diseases by initiating and …

Immune thrombocytopenia (ITP) is mediated by platelet autoantibodies that accelerate
platelet destruction and inhibit their production. Most cases are considered idiopathic …

Primary immune deficiency diseases (PID) comprise a genetically heterogeneous group of
disorders that affect distinct components of the innate and adaptive immune system, such as …

Autoimmune lymphoproliferative syndrome (ALPS) is a rare disorder of apoptosis. It is
frequently caused by mutations in FAS (TNFRSF6) gene. Unlike most of the self-limiting …

Although primary immunodeficiency diseases (PIDs) were first reported in India in the
1970s, those diagnoses were based predominantly on clinical presentations—very limited …

Primary immune thrombocytopenia (ITP) is an immune-mediated bleeding disorder
characterized by decreased platelet counts and an increased risk of bleeding. Multiple …