The novel AKT inhibitor perifosine possesses myelopoiesis-stimulating effects in rodents.
We studied the in vitro effects of the novel agents perifosine, bortezomib and lenalidomide in …

The serine/threonine kinase Akt, a downstream effector of phosphatidylinositol 3-kinase
(PI3K), is known to play an important role in antiapoptotic signaling and has been implicated …

The serine/threonine kinase Akt, a downstream effector of phosphatidylinositol 3-kinase
(PI3K), is known to play an important role in antiapoptotic signaling and has been implicated …

The stem cells of the bone marrow have the capacity for both self-renewal and derivation of
all the blood cell lineages. Consequently, toxicity to these cells can result in neutropenia …

Introduction: Perifosine is a novel targeted oral Akt inhibitor. In preclinical leukemia models,
perifosine has an independent cytotoxic potential but also synergizes well with other …

Perifosine is an Akt inhibitor displaying strong antineoplastic effects in human tumor cell
lines and is currently being tested in phase II clinical trials for treatment of major human …

OBJECTIVE: In addition to neutropenias and/or thrombocytopenias as a short-term effect,
antineoplastics also can produce long-term effects as a consequence of damage to the …

Anagrelide (ANA) and hydroxycarbamide (HC) are two distinct pharmacological agents
used to treat thrombocythaemia associated with myeloproliferative disorders. Although both …

Current cytotoxic treatment regimens are most frequently dose-limited by the problem of
myelotoxicity, and this could theoretically be prevented or reduced by the use of stem-cell …

This study compares the effects of a high dose of methotrexate (HDMTX) to that of a high
dose of methotrexate plus leucovorin protection on the hemopoietic stem cells in a murine …