The peripheral antinociceptive effect of the selective COX-2 inhibitor celecoxib in the
formalin-induced inflammatory pain was compared with that of resveratrol (COX-1 inhibitor) …

Celecoxib is a selective inhibitor of cyclooxygenase-2 (COX-2) and blocks prostaglandin
(PG) biosynthesis associated with inflammatory conditions. In a model of peripherally …

Objective and design The antinociception induced by the intraperitoneal coadministration in
mice of combinations of metamizol and paracetamol was evaluated in the tail flick test and …

Background: The analgesic effects of celecoxib, a cyclooxygenase‐2 (COX‐2) inhibitor, on
formalin‐induced pain are still controversial. The purpose of this study was to examine the …

Non-steroidal antiinflammatory drugs (NSAIDs) are known to induce analgesia mainly via
inhibition of cyclooxygenase (COX). Although the inhibition of COX in the periphery is …

Studies with inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 inhibitor were
conducted to assess their synergistic antinociceptive effect and possible therapeutic …

Synergism has been used to obtain analgesia at doses at which side effects are minimal. In
addition, it has been demonstrated that inhibition of cyclooxygenase-2 is responsible for the …

OBJECTIVES: Freund's complete adjuvant (FCA) is an animal model of inflammatory pain
commonly used in the screening of COX-inhibitors. However, there is little understanding of …

Non-steroidal antiinflammatory drugs (NSAIDs) inhibit the cyclooxygenase (COX) enzyme
and so they are effective analgesic, antiinflammatory and antipyretic drugs. The discovery of …

Administration of formalin in rat paws results in stimulation of nociceptive pathways, which
leads to an increase in the excitability of neurons present in dorsal horn. This increased …