Despite the fact that deregulated NLRP3 inflammasome activation contributes to the
pathogenesis of chronic inflammatory or metabolic disorders, the underlying mechanism by …

Inflammasomes are multimeric protein complexes that induce the cleavage and release of
bioactive IL-1β and cause a lytic form of cell death, termed pyroptosis. Due to its diverse …

The NLRP3 inflammasome is activated by a variety of external or host-derived stimuli and its
activation initiates an inflammatory response through caspase-1 activation, resulting in …

A current paradigm proposes that mitochondrial damage is a critical determinant of NLRP 3
inflammasome activation. Here, we genetically assess whether mitochondrial signalling …

The NLRP3 inflammasome is a multiprotein platform which is activated upon cellular
infection or stress. Its activation leads to caspase-1-dependent secretion of proinflammatory …

Twenty-four hours of fasting is known to blunt activation of the human NLRP3
inflammasome. This effect might be mediated by SIRT3 activation, controlling mitochondrial …

NLRP3 inflammasome‐dependent inflammatory responses are triggered by a variety of
signals of host danger, including infection, tissue damage and metabolic dysregulation. How …

The nod‐like receptor protein 3 (NLRP3) inflammasome drives inflammation in response to
mitochondrial dysfunction. As metabolic powerhouses with prokaryotic ancestry …

The NLRP3 inflammasome is assembled and activated in certain types of myeloid cells
upon sensing microbe-derived toxins or host-derived danger signals. Activation of the …

The NLRP3 inflammasome is a cytosolic complex that activates Caspase-1, leading to
maturation of interleukin-1β (IL-1β) and IL-18 and induction of proinflammatory cell death in …