Highlights•Androgen receptor (AR) signaling is a critical driver of prostate cancer cell
proliferation and survival.•Alterations in AR and peripheral production of androgens promote …

Androgens play a critical role in the progression of castration-resistant prostate cancer
through androgen receptor (AR)-regulated signaling pathways. Progress has been made in …

The androgen signaling axis has been the main therapeutic target in the management of
advanced prostate cancer for several decades. Over the past years, significant advances …

Androgen receptor (AR)-mediated signaling is critical to the growth and survival of prostate
cancer. Although medical castration and antiandrogen therapy can decrease AR activity and …

Activation of the androgen receptor (AR) and AR-driven transcriptional programs is central to
the pathophysiology of prostate cancer. Despite successful translational efforts in targeting …

Despite recent advances in the treatment of advanced prostate cancer (PCa), metastatic
castrate-resistant PCa remains incurable at this time. The androgen receptor (AR) plays a …

Recent genomic analyses of metastatic prostate cancer have provided important insight into
adaptive changes in androgen receptor (AR) signaling that underpin resistance to androgen …

Owing to the development of multiple novel therapies, there has been major progress in the
treatment of advanced prostate cancer over the last two decades; however, the disease …

Androgen receptor (AR) signaling is a critical pathway for prostate cancer cells, and
androgen-deprivation therapy (ADT) remains the principal treatment for patients with locally …

Simple Summary Prostate cancer progression is mainly driven by the androgen receptor
(AR) signaling pathway and its inhibition has been the cornerstone in the treatment of …