Purpose Inflammation plays a critical role in cancer progression. In this study we investigate
the pro-tumorigenic activities and gene expression profiles of lung cancer cells after …

Macrophages are widely distributed innate immune cells that play indispensable roles in the
innate and adaptive immune response to pathogens and in‐tissue homeostasis …

Lung cancer is the leading cause of cancer mortality worldwide, and at only 18%, it has one
of the lowest 5-year survival rates of all malignancies. With its highly complex mutational …

The focus of the present study was whether and how infiltrating macrophages play a role in
angiogenesis and the growth of cancer cells in response to the inflammatory cytokine …

Rationale: Recent studies indicate that tumor-associated macrophages (MΦ) with an M2
phenotype can influence cancer progression and metastasis, but the regulatory pathways …

OBJECTIVE: It remains largely unknown whether tumor-associated macrophages (TAMs)
are involved in invasion and metastasis of human lung cancer. The aim of our study was to …

Tumor-associated macrophages are a major constituent of malignant tumors and are known
to stimulate key steps in tumor progression. In our review in this journal in 2006, we …

Cancer progression is a complex multi-step process that consists of transformation, tumor
growth, invasion and metastasis. Tumor invasion and metastasis are the critical steps in …

Purpose: To evaluate the interaction between tumor-infiltrating macrophages and cancer
cells and its effect on the expression of a potent angiogenic factor, interleukin-8 (IL-8), tumor …

Cancer and metastasis are closely associated with inflammation. Macrophages are
important effector cells in enhancing tumor proliferation, invasion and providing protection …