PTEN is a potent tumour suppressor, and its loss of function is frequently observed in both
heritable and sporadic cancers. PTEN has phosphatase-dependent and phosphatase …

The PTEN tumor suppressor was discovered by its homozygous deletion and other
mutations in cancer. Since then, PTEN has been shown to be a non-redundant …

PTEN is the most important negative regulator of the PI3K signaling pathway. In addition to
its canonical, PI3K inhibition-dependent functions, PTEN can also function as a tumor …

PTEN (also known as MMAC-1 or TEP-1) is one of the most frequently mutated tumor
suppressors in human cancer. It is also essential for embryonic development. PTEN …

The PTEN (phosphatase and tensin homologue deleted on chromosome 10) tumour
suppressor is a PI (phosphoinositide) 3-phosphatase that can inhibit cellular proliferation …

The tumor suppressor PTEN controls a variety of biological processes including cell
proliferation, growth, migration, and death. As a master cellular regulator, PTEN itself is also …

The importance of PTEN in cellular function is underscored by the frequency of its
deregulation in cancer. PTEN tumor-suppressor activity depends largely on its lipid …

The PTEN tumour suppressor gene is mutated frequently in many malignancies and its
importance in the development of cancer is probably underestimated. As the primary …

Proteoforms are specific molecular forms of protein products arising from a single gene that
possess different structures and different functions. Therefore, a single gene can produce a …

Since its discovery as the elusive tumor suppressor gene at the frequently mutated 10q23
locus, PTEN has been identified as lost or mutated in several sporadic and heritable tumor …