The functions and regulation of the PTEN tumour suppressor: new modes and prospects
PTEN is a potent tumour suppressor, and its loss of function is frequently observed in both
heritable and sporadic cancers. PTEN has phosphatase-dependent and phosphatase …
heritable and sporadic cancers. PTEN has phosphatase-dependent and phosphatase …
The role of PTEN signaling perturbations in cancer and in targeted therapy
M Keniry, R Parsons - Oncogene, 2008 - nature.com
The PTEN tumor suppressor was discovered by its homozygous deletion and other
mutations in cancer. Since then, PTEN has been shown to be a non-redundant …
mutations in cancer. Since then, PTEN has been shown to be a non-redundant …
PTEN: multiple functions in human malignant tumors
M Milella, I Falcone, F Conciatori, U Cesta Incani… - Frontiers in …, 2015 - frontiersin.org
PTEN is the most important negative regulator of the PI3K signaling pathway. In addition to
its canonical, PI3K inhibition-dependent functions, PTEN can also function as a tumor …
its canonical, PI3K inhibition-dependent functions, PTEN can also function as a tumor …
Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosis
KM Yamada, M Araki - Journal of cell science, 2001 - journals.biologists.com
PTEN (also known as MMAC-1 or TEP-1) is one of the most frequently mutated tumor
suppressors in human cancer. It is also essential for embryonic development. PTEN …
suppressors in human cancer. It is also essential for embryonic development. PTEN …
PTEN function: how normal cells control it and tumour cells lose it
NR Leslie, CP Downes - Biochemical Journal, 2004 - portlandpress.com
The PTEN (phosphatase and tensin homologue deleted on chromosome 10) tumour
suppressor is a PI (phosphoinositide) 3-phosphatase that can inhibit cellular proliferation …
suppressor is a PI (phosphoinositide) 3-phosphatase that can inhibit cellular proliferation …
PTEN: a default gate-keeping tumor suppressor with a versatile tail
X Wang, X Jiang - Cell research, 2008 - nature.com
The tumor suppressor PTEN controls a variety of biological processes including cell
proliferation, growth, migration, and death. As a master cellular regulator, PTEN itself is also …
proliferation, growth, migration, and death. As a master cellular regulator, PTEN itself is also …
PTEN: from pathology to biology
ML Sulis, R Parsons - Trends in cell biology, 2003 - cell.com
The PTEN tumour suppressor gene is mutated frequently in many malignancies and its
importance in the development of cancer is probably underestimated. As the primary …
importance in the development of cancer is probably underestimated. As the primary …
PTEN proteoforms in biology and disease
Proteoforms are specific molecular forms of protein products arising from a single gene that
possess different structures and different functions. Therefore, a single gene can produce a …
possess different structures and different functions. Therefore, a single gene can produce a …
Tenets of PTEN tumor suppression
Since its discovery as the elusive tumor suppressor gene at the frequently mutated 10q23
locus, PTEN has been identified as lost or mutated in several sporadic and heritable tumor …
locus, PTEN has been identified as lost or mutated in several sporadic and heritable tumor …