[HTML][HTML] Hybrid nanoparticles improve targeting to inflammatory macrophages through phagocytic signals

V Bagalkot, MA Badgeley, T Kampfrath… - Journal of controlled …, 2015 - Elsevier
Macrophages are innate immune cells with great phenotypic plasticity, which allows them to
regulate an array of physiological processes such as host defense, tissue repair, and …

Enhancing inflammation targeting using tunable leukocyte-based biomimetic nanoparticles

A Zinger, M Sushnitha, T Naoi, G Baudo, E De Rosa… - ACS …, 2021 - ACS Publications
Biomimetic nanoparticles aim to effectively emulate the behavior of either cells or exosomes.
Leukocyte-based biomimetic nanoparticles, for instance, incorporate cell membrane …

[HTML][HTML] Biomimetic nanoparticles for inflammation targeting

K Jin, Z Luo, B Zhang, Z Pang - Acta Pharmaceutica Sinica B, 2018 - Elsevier
There have been many recent exciting developments in biomimetic nanoparticles for
biomedical applications. Inflammation, a protective response involving immune cells, blood …

[HTML][HTML] Biomimetic nanoparticles with enhanced affinity towards activated endothelium as versatile tools for theranostic drug delivery

JO Martinez, R Molinaro, KA Hartman, C Boada… - Theranostics, 2018 - ncbi.nlm.nih.gov
Activation of the vascular endothelium is characterized by increased expression of vascular
adhesion molecules and chemokines. This activation occurs early in the progression of …

Biomimetic proteolipid vesicles for targeting inflamed tissues

R Molinaro, C Corbo, JO Martinez, F Taraballi… - Nature materials, 2016 - nature.com
A multitude of micro-and nanoparticles have been developed to improve the delivery of
systemically administered pharmaceuticals, which are subject to a number of biological …

Inflamed leukocyte-mimetic nanoparticles for molecular imaging of inflammation

X Chen, R Wong, I Khalidov, AY Wang… - Biomaterials, 2011 - Elsevier
Dysregulated host inflammatory response causes many diseases, including cardiovascular
and neurodegenerative diseases, cancer, and sepsis. Sensitive detection of the site of …

Phase‐Separated Liposomes Hijack Endogenous Lipoprotein Transport and Metabolism Pathways to Target Subsets of Endothelial Cells In Vivo

G Arias‐Alpizar, P Papadopoulou… - Advanced …, 2023 - Wiley Online Library
Plasma lipid transport and metabolism are essential to ensure correct cellular function
throughout the body. Dynamically regulated in time and space, the well‐characterized …

Imaging macrophages with nanoparticles

R Weissleder, M Nahrendorf, MJ Pittet - Nature materials, 2014 - nature.com
Nanomaterials have much to offer, not only in deciphering innate immune cell biology and
tracking cells, but also in advancing personalized clinical care by providing diagnostic and …

Neutrophils enable local and non‐invasive liposome delivery to inflamed skeletal muscle and ischemic heart

J Che, A Najer, AK Blakney, PF McKay… - Advanced …, 2020 - Wiley Online Library
Uncontrolled inflammation is a major pathological factor underlying a range of diseases
including autoimmune conditions, cardiovascular disease, and cancer. Improving localized …

Structural and componential design: new strategies regulating the behavior of lipid-based nanoparticles in vivo

Q Zhong, C Zheng, K Yi, RL Mintz, S Lv, Y Tao… - Biomaterials …, 2023 - pubs.rsc.org
Lipid-based nanoparticles have made a breakthrough in clinical disease as delivery
systems due to their biocompatibility, thermal and long-term stability, high loading ability …