During multiple sclerosis (MS), an inflammatory and neurodegenerative disease of the
central nervous system (CNS), symptoms, and outcomes are determined by the location of …

Astrocytes are crucial regulators of innate and adaptive immune responses in the injured
central nervous system. Depending on timing and context, astrocyte activity may exacerbate …

Astrocytes have many functions in the central nervous system (CNS). They support
differentiation and homeostasis of neurons and influence synaptic activity. They are …

The central nervous system (CNS) is considered to be immune privileged, owing in part to
the absence of major histocompatibility (MHC) class II+ cells in the healthy brain …

Neuroinflammation is an escalation factor shared by a vast range of central nervous system
(CNS) pathologies, from neurodegenerative diseases to neuropsychiatric disorders. CNS …

Multiple Sclerosis (MS) is an inflammatory disease of the Central Nervous System (CNS)
that causes the demyelination of nerve cells and destroys oligodendrocytes, neurons and …

Factors that regulate leukocyte entry and spread through CNS parenchyma during different
types of CNS insults are incompletely understood. Reactive astrocytes have been implicated …

Astrocytes regulate fundamentally important functions to maintain central nervous system
(CNS) homeostasis. Altered astrocytic function is now recognized as a primary contributing …

Astrocytic contributions to neuroinflammation are widely implicated in disease, but they
remain incompletely explored. We assess medial prefrontal cortex (PFC) and visual cortex …

Astrocytes form borders (glia limitans) that separate neural from non-neural tissue along
perivascular spaces, meninges and tissue lesions in the CNS. Transgenic loss-of-function …