MAIT cells are imprinted by the microbiota in early life and promote tissue repair
MG Constantinides, VM Link, S Tamoutounour… - Science, 2019 - science.org
INTRODUCTION The microbiota promotes the maturation and homeostasis of the immune
system, in part through the release of microbial products. Early-life microbial colonization …
system, in part through the release of microbial products. Early-life microbial colonization …
MAIT cell development and functions: the microbial connection
F Legoux, M Salou, O Lantz - Immunity, 2020 - cell.com
Mucosal-associated invariant T (MAIT) cells are an evolutionarily conserved T cell subset,
which reacts to most bacteria through T cell receptor (TCR)-mediated recognition of …
which reacts to most bacteria through T cell receptor (TCR)-mediated recognition of …
[HTML][HTML] Tuning of human MAIT cell activation by commensal bacteria species and MR1-dependent T-cell presentation
Human mucosal-associated invariant T (MAIT) cell receptors (TCRs) recognize bacterial
riboflavin pathway metabolites through the MHC class 1-related molecule MR1. However, it …
riboflavin pathway metabolites through the MHC class 1-related molecule MR1. However, it …
Microbial metabolites control the thymic development of mucosal-associated invariant T cells
F Legoux, D Bellet, C Daviaud, Y El Morr, A Darbois… - Science, 2019 - science.org
How the microbiota modulate immune functions remains poorly understood. Mucosal-
associated invariant T (MAIT) cells are implicated in mucosal homeostasis and absent in …
associated invariant T (MAIT) cells are implicated in mucosal homeostasis and absent in …
Early-life imprinting of unconventional T cells and tissue homeostasis
MG Constantinides, Y Belkaid - Science, 2021 - science.org
BACKGROUND In addition to providing antimicrobial immunity, the immune system governs
numerous aspects of host physiology, in part through the coordinated action of tissue …
numerous aspects of host physiology, in part through the coordinated action of tissue …
[HTML][HTML] MAIT cells, guardians of skin and mucosa?
I Nel, L Bertrand, A Toubal, A Lehuen - Mucosal immunology, 2021 - Elsevier
Abstract Mucosal Associated Invariant T (MAIT) cells are evolutionary conserved innate-like
T cells able to recognize bacterial and fungal ligands derived from vitamin B biosynthesis …
T cells able to recognize bacterial and fungal ligands derived from vitamin B biosynthesis …
MAIT cell activation and functions
TSC Hinks, XW Zhang - Frontiers in immunology, 2020 - frontiersin.org
Mucosal associated invariant T (MAIT) cells are striking in their abundance and their strict
conservation across 150 million years of mammalian evolution, implying they must fulfill …
conservation across 150 million years of mammalian evolution, implying they must fulfill …
MAIT cells in health and disease
NM Provine, P Klenerman - Annual review of immunology, 2020 - annualreviews.org
Mucosal-associated invariant T (MAIT) cells have been attracting increasing attention over
the last few years as a potent unconventional T cell subset. Three factors largely account for …
the last few years as a potent unconventional T cell subset. Three factors largely account for …
[HTML][HTML] Single-cell transcriptional profiling reveals signatures of helper, effector, and regulatory MAIT cells during homeostasis and activation
Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes that recognize
microbial vitamin B metabolites and have emerging roles in infectious disease …
microbial vitamin B metabolites and have emerging roles in infectious disease …
[HTML][HTML] Activation and in vivo evolution of the MAIT cell transcriptome in mice and humans reveals tissue repair functionality
TSC Hinks, E Marchi, M Jabeen, M Olshansky… - Cell reports, 2019 - cell.com
Mucosal-associated invariant T (MAIT) cells are MR1-restricted innate-like T cells conserved
across mammalian species, including mice and humans. By sequencing RNA from sorted …
across mammalian species, including mice and humans. By sequencing RNA from sorted …