Fish are ideally suited for in vivo-imaging due to their transparency at early stages combined
with a large genetic toolbox. Key challenges to further advance imaging are fluorophore …

Direct tests of gene function have historically been performed in a limited number of model
organisms. The CRISPR/Cas system is species-agnostic, offering the ability to manipulate …

The ability to carry out high-resolution, high-magnification optical imaging of living animals is
one of the most attractive features of the zebrafish as a model organism. However …

Body pigmentation is a limitation for in vivo imaging and thus for the performance of
longitudinal studies in biomedicine. A possibility to circumvent this obstacle is the …

Zebrafish is now widely used in biomedical research as a model for human diseases, but the
relevance of the model depends on a rigorous analysis of the phenotypes obtained. Many …

Understanding the ephemeral changes that occur during brain development and maturation
requires detailed high-resolution imaging in space and time at cellular and subcellular …

Genomic manipulation is a useful approach for elucidating the molecular pathways
underlying aspects of development, physiology, and behaviour. However, a lack of gene …

With many live imaging techniques, it is crucial that a deep level of anesthesia is reached
and maintained throughout image acquisition without reducing zebrafish viability. This is …

Cephalopods are remarkable among invertebrates for their cognitive abilities, adaptive
camouflage, novel structures, and propensity for recoding proteins through RNA editing …

High-resolution time-lapse imaging of living zebrafish larvae can be utilized to visualize how
biological processes unfold (for review see 1). Compound transgenic fish which express …