Background Alzheimer's disease (AD) is a neurodegenerative disorder characterized by
deposition of amyloid plaques and disruption of neural circuitry, leading to cognitive decline …

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease characterized by
aggregation of amyloid-β (Aβ) peptide in the hippocampus and cortex of brain …

Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine kinase that is activated by the
neuron specific activators p35/p39 and plays many important roles in neuronal …

Centella asiatica is a medicinal plant used to enhance memory. We have previously shown
that a water extract of Centella asiatica (CAW) attenuates β-amyloid (Aβ)-induced spatial …

Background: The medicinal herb Centella asiatica has been long been used for its
neuroprotective and cognitive enhancing effects. We have previously shown that two weeks …

Recent studies have shown that learning and memory capacity is disturbed in depressive
patients, and it is important to reveal the effects of antidepressant drugs on cognitive function …

Resveratrol, a natural polyphenol found in red wine, has wide spectrum of pharmacological
properties including antioxidative and antiaging activities. Beta amyloid peptides (Aβ) are …

Sigma-1 receptor agonists have recently gained a great deal of interest due to their anti-
amnesic, neuroprotective, and neurorestorative properties. Compounds such as PRE-084 or …

Background Moderate to severe Alzheimer's disease (AD) is characterized by a high degree
of cognitive, functional, and behavioral dysfunction. There are relatively few treatments …

We examined the effects of ibuprofen on cognitive deficits, Aβ and tau accumulation in
young triple transgenic (3xTg-AD) mice. 3xTg-AD mice were fed ibuprofen-supplemented …