Alzheimer's disease (AD) is characterized by early impairments in memory and progressive
neurodegeneration. Disruption of synaptic plasticity processes that underlie learning and …

Alzheimer's disease (AD) is a progressive degenerative disorder characterized by the
presence of amyloid deposits, neurofibrillary tangles and neuron loss. Emerging evidence …

Alzheimer's disease (AD) is a chronic neurodegenerative disorder which can contribute to
memory loss and cognitive damage in the elderly; moreover, evidence from clinical and …

Background: The neuroinflammation characterized by glial activation and release of
proinflammatory mediators is considered to play a critical role in the pathogenesis of …

Alzheimer's disease (AD) is a complex neurodegenerative disorder with cognitive
impairment and major neuropathologic hallmark of amyloid-beta (Aβ) peptides. Risperidone …

Background: Inflammation promotes the progression of Alzheimer's disease (AD). In this
study, we explored the effect of dexmedetomidine on inflammation and cognitive function in …

Background: Alzheimer's disease (AD), the most common form of dementia, remains long-
term and challenging to diagnose. Furthermore, there is currently no medication to …

Phosphodiesterases (PDEs) are enzymes that hydrolyze and inactivate 3′, 5′-cyclic
adenosine monophosphate (cAMP) and/or 3′, 5′-cyclic guanosine monophosphate …

Background Collective evidences have indicated that intracellular accumulation of
hyperphosphorylated tau forms neurofibrillary tangles in the brain, which impairs memory …

Misfolded amyloid beta peptide (Aβ) is a pathological hallmark of Alzheimer's disease (AD),
a neurodegenerative illness characterized by cognitive deficits and neuronal loss …