Background: Vitamin D (VD) and resveratrol (RSV) are two nutritional molecules that have
reported neuroprotective effects, and findings from cellular models suggest that resveratrol …

Alzheimer's disease (AD) is a progressive neurodegenerative disease that causes cognitive
impairment. Major pathophysiological AD characteristics include numerous senile plaque …

Alzheimer's disease (AD) is characterized by extracellular amyloid plaques composed of β-
amyloid (Aβ) and intracellular neurofibrillary tangles containing hyperphosphorylated tau …

Rationale The neural basis of depression-associated cognitive impairment remains poorly
understood, and the effect of antidepressants on learning and synaptic plasticity in animal …

In this study, we investigated the long-term treatment of dantrolene on amyloid and tau
neuropathology, brain volume, and cognitive function in aged triple transgenic Alzheimer …

Alzheimer's disease (AD) is a prevalent neurological disorder affecting memory function in
elderly persons. Indeed, AD exhibits abnormality in cognitive behaviors and higher …

Fluoxetine, a selective serotonin reuptake inhibitor, is neuroprotective; therefore, it has been
applied to treat some neurodegenerative disorders. For instance, chronic fluoxetine …

Our previous experiments demonstrated that social isolation (SI) caused AD-like tau
hyperphosphorylation and spatial memory deficits in middle-aged rats. However, the …

Ceramides, structural components of the cell, are known to play a range of roles in glucose
metabolism and apoptosis. C16-ceramide, an abundant molecular species of endogenous …

Functional and ultrastructural investigations support the concept that altered brain
connectivity, exhausted neural plasticity, and synaptic loss are the strongest correlates of …