In spite of over half a century of research, sepsis still constitutes a major problem in health
care delivery. Although advances in research have significantly increased our knowledge of …

Development of organ dysfunction discriminates sepsis from uncomplicated infection. The
paradigm shift implicated by the new sepsis-3 definition holds that initial impairment of any …

Acute kidney injury (AKI) remains a major clinical event with rising incidence, severity, and
cost; it now has a morbidity and mortality exceeding acute myocardial infarction. There is …

Acute kidney injury (AKI) remains to be an independent risk factor for mortality and morbidity.
Inflammation is now believed to play a major role in the pathopathophysiology of AKI. It is …

Background: Worldwide, both acute kidney injury (AKI) and sepsis are significant clinical
complications, particularly in critical care patients. Sepsis is an important cause of AKI, and …

Sepsis-induced AKI (SIAKI) is the most common complication with unacceptable mortality in
hospitalized and critically ill patients. The pathophysiology of the development of SIAKI is …

Septic acute kidney injury accounts for close to 50% of all cases of acute kidney injury in the
intensive care unit and, in its various forms, affects between 15% and 20% of intensive care …

Acute kidney injury (AKI) and sepsis carry consensus definitions. The simultaneous
presence of both identifies septic AKI. Septic AKI is the most common AKI syndrome in ICU …

Sepsis and acute kidney injury (AKI) frequently are combined in critical care patients. They
both are associated independently with increased mortality and morbidity. AKI may precede …

Ischemic kidney injury often occurs in the context of multiple organ failure and sepsis. Here,
we review the major components of this dynamic process, which involves hemodynamic …